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Matrix Metalloproteinases And Aggrecanase: Their Role in Disorders of the Human Intervertebral Disc
Study Design. A comprehensive immunohistochemical study of matrix metalloproteinase activity in discs from patients with different disc diseases.— Objectives. To identify individual matrixExpand
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Proteolytic Activities of Human ADAMTS-5
Aggrecanases have been characterized as proteinases that cleave the Glu373-Ala374 bond of the aggrecan core protein, and they are multidomain metalloproteinases belonging to the ADAMTS (adamalysinExpand
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Altered Proteolytic Activities of ADAMTS-4 Expressed by C-terminal Processing*
ADAMTS-4 (a disintegrin and metalloprotease with thrombospondin motifs) is a multidomain metalloproteinase belonging to the reprolysin family. The enzyme cleaves aggrecan core protein at severalExpand
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The Role of Human HtrA1 in Arthritic Disease*
Human HtrA1 belongs to a widely conserved family of serine proteases involved in various aspects of protein quality control and cell fate. Although HtrA1 has been implicated in the pathology ofExpand
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Mapping by monoclonal antibody detection of glycosaminoglycans in connective tissues
Chondroitin sulphate proteoglycans are widespread connective tissue components1–4 and chemical analysis of cartilage and other proteoglycans has demonstrated molecular speciation involving the degreeExpand
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Articular cartilage superficial zone protein (SZP) is homologous to megakaryocyte stimulating factor precursor and Is a multifunctional proteoglycan with potential growth-promoting, cytoprotective,
We have performed cDNA sequencing and homology analyses to elucidate the complete amino acid composition for a superficial zone protein (SZP) from human and bovine cartilage which has previously beenExpand
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Immunodetection and partial cDNA sequence of the proteoglycan, superficial zone protein, synthesized by cells lining synovial joints
We have previously described a large proteoglycan named superficial zone protein that was isolated and purified from culture medium of superficial slices of bovine articular cartilage. MonoclonalExpand
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TIMP‐3 inhibits aggrecanase‐mediated glycosaminoglycan release from cartilage explants stimulated by catabolic factors
Aggrecanases are considered to play a key role in the destruction of articular cartilage during the progression of arthritis. Here we report that the N‐terminal inhibitory domain of tissue inhibitorExpand
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Mechanisms involved in cartilage proteoglycan catabolism.
The increased catabolism of the cartilage proteoglycan aggrecan is a principal pathological process which leads to the degeneration of articular cartilage in arthritic joint diseases. The consequentExpand
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Production and characterization of monoclonal antibodies directed against connective tissue proteoglycans.
Monoclonal antibodies have been raised against determinants present in cartilage proteoglycan. Characterization of the specificity of these antibodies indicated that they recognize determinantsExpand
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