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Sequential changes of energy metabolism and mitochondrial function in myocardial infarction induced by isoproterenol in rats: a long-term and integrative study.
Acute myocardial infarction is the second cause of mortality in most countries, therefore, it is important to know the evolution and sequence of the physiological and biochemical changes involved inExpand
Functional effects of enhancing or silencing adenosine A2b receptors in cardiac fibroblasts.
Results derived from the molecular manipulation of receptor levels indicate that A2bR are critically involved in ADO-mediated inhibition of CF functions. Expand
Day-night cycle of lipid peroxidation in rat cerebral cortex and their relationship to the glutathione cycle and superoxide dismutase activity
It is proposed that fluctuations in lipoperoxidation, glutathione cycle components and superoxide dismutase activity could act as a physiological oscillator with an important role in modulating the membrane properties of the nerve cell. Expand
Adenosine partially prevents cirrhosis induced by carbon tetrachloride in rats
Adenosine administration was tested in rats with carbon tetrachloride–induced hepatic fibrosis and was able to partially prevent the enlargement of liver and spleen induced by the toxin, accompanied by a 50% reduction of the liver collagen deposition and preservation of content of glycosaminoglycans. Expand
Functional role of intravascular coronary endothelial adenosine receptors.
The data indicate that selective activation of intravascular coronary purine receptors may cause the release of endothelial bioactive messengers that regulate the function and metabolism of vascular and cardiac cells. Expand
Twenty-four-hour changes of S-adenosylmethionine, S-adenosylhomocysteine adenosine and their metabolizing enzymes in rat liver; possible physiological significance in phospholipid methylation.
The similarity of the adenosine and S-adenosylmethionine profiles through the 24-hr cycle suggests a role ofAdenosine in transmethylation reactions, because, during the night (02:00 hr), the metabolic conditions favor the formation and accumulation of S- adenosylhomocysteine (SAH), with consequent inhibition of transm methylation reactions. Expand
Role of the transient receptor potential vanilloid type 1 receptor and stretch-activated ion channels in nitric oxide release from endothelial cells of the aorta and heart in rats.
The authors conclude that SACs and the TRPV1 receptor are both present in the coronary endothelium and that both participate in Ca(2+)-dependent NO release. Expand
Functional and autoradiographic characterization of dopamine D2-like receptors in the guinea pig heart.
The results suggest that D3 and D4 receptors are functionally active in the heart, and need additional information with an antagonist and an agonist of improved potency and selectivity to understand the respective roles of D2 and D3 receptors in the cardiac functions. Expand
Circadian variations of adenosine level in blood and liver and its possible physiological significance.
The results suggest that liver purine metabolism might participate in the maintenance and renewal of the blood purine pool and in the energy state of erythrocytes in vivo. Expand
Implications of the coronary vascular endothelium as mediator of the vasodilatory and dromotropic actions of adenosine.
The results demonstrate that intravascular infusion of the microsphere XAC conjugates abolishes the vasodilatory and negative dromotropic effects of infused adenosine, and inhibits the dromotrop effects of hypoxia. Expand