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N,N-dimethylarginine

Known as: N(G1),N(G1)-dimethylarginine, N(G)-dimethylarginine, N(5)-((dimethylamino)iminomethyl)-L-ornithine 
A methylated derivative of L-arginine that is a competitive inhibitor of nitric oxide synthase (NOS). Asymmetric dimethylarginine (ADMA) is formed… 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (2)

ArginineEnzyme Inhibitors
N,N'-dimethylarginineanalogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Mechanisms of homocysteine-induced oxidative stress.
Hyperhomocysteinemia decreases vascular reactivity and is associated with cardiovascular morbidity and mortality. However… 
Highly Cited
2003
Highly Cited
2003
A Proteomic Analysis of Arginine-methylated Protein Complexes*
Arginine methylation is a post-translational modification that results in the formation of asymmetrical and symmetrical… 
Highly Cited
2002
Highly Cited
2002
The Novel Human Protein Arginine N-Methyltransferase PRMT6 Is a Nuclear Enzyme Displaying Unique Substrate Specificity*
Protein arginine methylation is a prevalent posttranslational modification in eukaryotic cells that has been implicated in signal… 
Highly Cited
2002
Highly Cited
2002
Determination of arginine, asymmetric dimethylarginine, and symmetric dimethylarginine in human plasma and other biological samples by high-performance liquid chromatography.
Asymmetric dimethylarginine (ADMA), an endogenous inhibitor of nitric oxide synthase (NOS), may be related to reduced… 
Highly Cited
2001
Highly Cited
2001
Risk of acute coronary events and serum concentration of asymmetrical dimethylarginine
Review
2001
Review
2001
State of the Arg Protein Methylation at Arginine Comes of Age
Highly Cited
2001
Highly Cited
2001
Plasma concentrations of asymmetric dimethylarginine are increased in patients with type 2 diabetes mellitus.
Highly Cited
2000
Highly Cited
2000
Arginine N-Methyltransferase 1 Is Required for Early Postimplantation Mouse Development, but Cells Deficient in the Enzyme Are Viable
ABSTRACT Protein arginine N-methyltransferases have been implicated in a variety of processes, including cell proliferation… 
Highly Cited
1999
Highly Cited
1999
Endogenous nitric oxide synthase inhibitor: a novel marker of atherosclerosis.
BACKGROUND Exposure to risk factors such as hypertension or hypercholesterolemia decreases the bioavailability of endothelium… 
Highly Cited
1970
Highly Cited
1970
Isolation and Identification of Ng,Ng- and Ng,N'g-Dimethylarginine, Nε-Mono-, Di-, and Trimethyllysine, and Glucosylgalactosyl- and Galactosyl-δ-hydroxylysine from Human Urine
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