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N-Methyl-D-Aspartate Receptors

Known as: Receptors, N-Methyl-D-Aspartate, NMDA receptor, Receptors, N-Methylaspartate 
A class of ionotropic glutamate receptors characterized by affinity for N-methyl-D-aspartate. NMDA receptors have an allosteric binding site for… 
National Institutes of Health

Related topics

Related topics

26 relations
Calcium ChannelGRIN2A protein, humanGRIN2B protein, humanIn Blood

Broader (2)

Excitatory Amino Acid ReceptorGlutamate Receptor

Narrower (12)

Gprin1 protein, mouseN-methyl D-aspartate receptor subtype 2ANMDA receptor 2BNMDA receptor A1

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2005
Review
2005
N-methyl-D-aspartate Receptor Subtypes: Multiple Roles in Excitotoxicity and Neurological Disease
N-methyl-D-aspartate (NMDA) receptors are the major mediator of excitotoxicity. Although physiological activation of the NMDA… 
Highly Cited
1999
Highly Cited
1999
Serine racemase: a glial enzyme synthesizing D-serine to regulate glutamate-N-methyl-D-aspartate neurotransmission.
Although D amino acids are prominent in bacteria, they generally are thought not to occur in mammals. Recently, high levels of D… 
Review
1999
Review
1999
Memantine is a clinically well tolerated N-methyl-d-aspartate (NMDA) receptor antagonist—a review of preclinical data
Highly Cited
1999
Highly Cited
1999
PSD-95 promotes Fyn-mediated tyrosine phosphorylation of the N-methyl-D-aspartate receptor subunit NR2A.
Fyn, a member of the Src-family protein-tyrosine kinase (PTK), is implicated in learning and memory that involves N-methyl-D… 
Review
1998
Review
1998
Glycine and N-methyl-D-aspartate receptors: physiological significance and possible therapeutic applications.
Since the finding by [Johnson and Ascher (1987)][1] demonstrating that glycine enhances electrophysiological responses mediated… 
Highly Cited
1997
Highly Cited
1997
Ro 25-6981, a highly potent and selective blocker of N-methyl-D-aspartate receptors containing the NR2B subunit. Characterization in vitro.
The interaction of Ro 25-6981 with N-methyl-D-aspartate (NMDA) receptors was characterized by a variety of different tests in… 
Highly Cited
1993
Highly Cited
1993
Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors.
The effects of the atypical N-methyl-D-aspartate (NMDA) receptor antagonist ifenprodil were investigated by voltage-clamp… 
Highly Cited
1992
Highly Cited
1992
Open-channel block of N-methyl-D-aspartate (NMDA) responses by memantine: therapeutic advantage against NMDA receptor-mediated neurotoxicity
Excessive activation of NMDA receptors is thought to mediate the calcium-dependent neurotoxicity associated with hypoxic-ischemic… 
Highly Cited
1988
Highly Cited
1988
Cooperative Modulation of [3H]MK‐801 Binding to the N‐Methyl‐d‐Aspartate Receptor‐Ion Channel Complex by l‐Glutamate, Glycine, and Polyamines
Abstract: In extensively washed rat cortical membranes [3 H](+)‐ 5 ‐ methyl ‐ 10,11 ‐ dihydro ‐ 5 H‐ dibenzo [a,d]cyclohepten‐5… 
Highly Cited
1987
Highly Cited
1987
Zinc selectively blocks the action of N-methyl-D-aspartate on cortical neurons.
Large amounts of zinc are present in synaptic vesicles of mammalian central excitatory boutons and may be released during… 
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