Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies
Paraneoplastic anti–N‐methyl‐D‐aspartate receptor encephalitis associated with ovarian teratoma
The autoantigens of a new category of treatment‐responsive paraneoplastic encephalitis are reported, and it is proposed that this category should be combined with existing treatment-responsive encephalopathy categories.
Anti–N‐methyl‐D‐aspartate receptor (NMDAR) encephalitis in children and adolescents
To report the clinical features of anti–N‐methyl‐D‐aspartate receptor (NMDAR) encephalitis in patients ≤ 18 years old.
Cellular and Synaptic Mechanisms of Anti-NMDA Receptor Encephalitis
These studies establish the cellular mechanisms through which antibodies of patients with anti-NMDAR encephalitis cause a specific, titer-dependent, and reversible loss of NMDARs.
AMPA receptor antibodies in limbic encephalitis alter synaptic receptor location
To report the clinical and immunological features of a novel autoantigen related to limbic encephalitis (LE) and the effect of patients' antibodies on neuronal cultures.
Clinical evaluation of idiopathic paroxysmal kinesigenic dyskinesia
The diagnosis of idiopathic paroxysmal kinesigenic dyskinesia (PKD) can be made based on historical features, and the diagnostic scheme may allow better focus in the search for the PKD gene(s).
Anti-NMDA Receptor Encephalitis Antibody Binding Is Dependent on Amino Acid Identity of a Small Region within the GluN1 Amino Terminal Domain
- Amy J. Gleichman, L. Spruce, J. Dalmau, S. Seeholzer, D. Lynch
- BiologyJournal of Neuroscience
- 8 August 2012
A series of mutants within the amino terminal domain of GluN1 are created that change patient antibody binding in transfected cells in stereotyped ways, demonstrating that the N368/G369 region of GLUN1 is crucial for the creation of immunoreactivity.
ADCK3, an ancestral kinase, is mutated in a form of recessive ataxia associated with coenzyme Q10 deficiency.
Mutations in the gene PRRT2 cause paroxysmal kinesigenic dyskinesia with infantile convulsions.
Ontogeny of the serotonergic projection to rat neocortex: transient expression of a dense innervation to primary sensory areas.
The development of serotonergic innervation to rat cerebral cortex was characterized by immunohistochemical localization of serotonin combined with autoradiographic imaging of serotonin-uptake sites and may exert a trophic influence on the development of cortical circuitry and thalamocortical connections.