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N,N'-ethylenebis(iodoacetamide)

Known as: ethylenediamine bis(iodoacetamide) 
National Institutes of Health

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Broader (1)

Ethylenediamines

Papers overview

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2019
2019
Covalent modification of Cys-239 in β-tubulin by small molecules as a strategy to promote tubulin heterodimer degradation
Clinical microtubule-targeting drugs are functionally divided into microtubule-destabilizing and microtubule-stabilizing agents… 
2018
2018
Synthesis, molecular modeling and biological evaluation of potent analogs of 2-methoxyestradiol
Highly Cited
2010
Highly Cited
2010
Quick and Simple Detection Technique to Assess the Binding of Antimicrotubule Agents to the Colchicine-Binding Site
Development of antimitotic binding to the colchicine-binding site for the treatment of cancer is rapidly expanding. Numerous… 
1992
1992
Interaction of dolastatin 10 with bovine brain tubulin.
1987
1987
The interaction of cystamine with bovine brain tubulin.
Microtubule assembly in vitro is sensitive to a variety of non-physiological sulfhydryl-oxidizing agents, but the physiological… 
1985
1985
The effect of TN-16 on the alkylation of tubulin.
1985
1985
N,N'-Ethylene-bis(iodoacetamide) as a probe for structural and functional characteristics of brine shrimp, squid, and bovine tubulins.
We have developed a simple probe for certain functionally significant features of the tubulin molecule. When bovine brain tubulin… 
Highly Cited
1984
Highly Cited
1984
Different effects of tubulin ligands on the intrachain cross-linking of beta 1-tubulin.
When bovine brain tubulin purified in the absence of GTP and MgCl2 is reacted with N,N'-ethylene-bis(iodoacetamide) (EBI), a… 
Highly Cited
1981
Highly Cited
1981
Interaction of tubulin with drugs and alkylating agents. 1. Alkylation of tubulin by iodo[14C]acetamide and N,N'-ethylenebis(iodoacetamide).
The sulfhydryl groups of tubulin are reported to play a role in regulating microtubule assembly and colchicine binding to tubulin… 
Highly Cited
1981
Highly Cited
1981
Interaction of tubulin with drugs and alkylating agents. 2. Effects of colchicine, podophyllotoxin, and vinblastine on the alkylation of tubulin.
The antimitotic drugs colchicine, podophyllotoxin, and vinblastine are known to be potent inhibitors of microtubule… 
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