• Publications
  • Influence
PDZ Domain Interaction Controls the Endocytic Recycling of the Cystic Fibrosis Transmembrane Conductance Regulator*
A new role for PDZ proteins in regulating the endocytic recycling of CFTR in polarized epithelial cells is identified. Expand
Transport of ER vesicles on actin filaments in neurons by myosin V.
These studies provide the first direct evidence that ER vesicles are transported on actin Filaments by myosin V, and confirm the role of actin filaments in fast axonal transport and provide support for the dual filament model of vesicle transport. Expand
The Short Apical Membrane Half-life of Rescued ΔF508-Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Results from Accelerated Endocytosis of ΔF508-CFTR in Polarized Human Airway Epithelial
In polarized human airway epithelial cells (CFBE41o-) the ΔF508 mutation increased endocytosis of CFTR from the apical membrane without causing a globalendocytic defect or affecting the endocytic recycling ofCFTR in the Rab11a-specific apical recycling compartment. Expand
Fast transport of neurofilament protein along microtubules in squid axoplasm.
These observations demonstrate, for the first time, that fast (0.5-1.0 microm/second) transport of neurofilament proteins occurs along microtubules, and suggest that neurofilaments can be transported as non-membrane bound, nonfilamentous subunits along axons, and that the transport is kinesin-dependent. Expand
Membrane Trafficking of the Cystic Fibrosis Gene Product, Cystic Fibrosis Transmembrane Conductance Regulator, Tagged with Green Fluorescent Protein in Madin-Darby Canine Kidney Cells*
It is concluded that cAMP stimulates CFTR-mediated Cl− secretion in MDCK type I cells by activating channels resident in the apical plasma membrane. Expand
Myosin Vb Is Required for Trafficking of the Cystic Fibrosis Transmembrane Conductance Regulator in Rab11a-specific Apical Recycling Endosomes in Polarized Human Airway Epithelial Cells*
Data indicate that myosin Vb is required for CFTR recycling in Rab11a-specific apical recycling endosomes in polarized human airway epithelial cells. Expand
Myosin‐V, a Versatile Motor for Short‐Range Vesicle Transport
Myosin‐V is a versatile motor involved in short‐range transport of vesicles in the actin‐rich cortex of the cell and forms a complex with kinesin, a microtubule‐based motor. Expand
Actin- and microtubule-dependent organelle motors: interrelationships between the two motility systems.
  • G. Langford
  • Biology, Medicine
  • Current opinion in cell biology
  • 1995
Functional studies of unconventional myosins are beginning to provide insights into the role these motors play in membrane trafficking and organelle movement and the interrelationship between the two motility systems. Expand
Myosin superfamily evolutionary history
An analysis of the evolutionary history of the myosin superfamily suggests that early‐appearingMyosin families function as generalists, carrying out a number of functions in a variety of cell types, while more recently evolved myosIn families functionAs specialists and are limited to a few organisms or a few cell types within organisms. Expand
Actin-dependent organelle movement in squid axoplasm
Evidence is provided of a new type of organelle movement in squid axoplasm which is independent of both microtubules and microtubule-based motors and probably generated by a myosin-like motor. Expand