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Mutation Accumulation

Known as: Accumulation, Mutation, Accumulations, Mutation, Mutation Accumulations 
Concept which describes the incremental effects of MUTATION in living organisms.
National Institutes of Health

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AgingMutagenesis Process

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Spontaneous Mutation Accumulation

Papers overview

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2011
2011
No Evidence of Elevated Germline Mutation Accumulation Under Oxidative Stress in Caenorhabditis elegans
Variation in rates of molecular evolution has been attributed to numerous, interrelated causes, including metabolic rate, body… 
Review
2010
Review
2010
Cellular and sub-cellular pathology of animal prion diseases: relationship between morphological changes, accumulation of abnormal prion protein and clinical disease
The transmissible spongiform encephalopathies (TSEs) or prion diseases of animals are characterised by CNS spongiform change… 
2010
2010
Mutation accumulation in Tetrahymena
BackgroundThe rate and fitness effects of mutations are key in understanding the evolution of every species. Traditionally, these… 
2009
2009
Spectral properties and mechanisms that underlie autofluorescent accumulations in Batten disease.
2006
2006
Increase of the Spontaneous Mutation Rate in a Long-Term Experiment With Drosophila melanogaster
In a previous experiment, the effect of 255 generations of mutation accumulation (MA) on the second chromosome viability of… 
2005
2005
Behavioral Degradation Under Mutation Accumulation in Caenorhabditis elegans
Spontaneous mutations play a fundamental role in the maintenance of genetic variation in natural populations, the nature of… 
2005
2005
Biased mutation-assembling: an efficient method for rapid directed evolution through simultaneous mutation accumulation.
We have developed an efficient optimization technique, 'biased mutation-assembling', for improving protein properties such as… 
2005
2005
Mutation accumulation of the transcriptome
A microarray-based study of the nematode Caenorhabditis elegans offers a first glimpse of the effect of mutation accumulation on… 
2003
2003
Mutation accumulation in growing asexual lineages.
The stochastic loss of entire classes of individuals bearing the fewest number of mutations-a process known as Muller's ratchet… 
Highly Cited
2000
Highly Cited
2000
Estimation of microsatellite mutation rates in Drosophila melanogaster.
Microsatellite mutations were studied in a set of 175 mutation accumulation lines, all of them independently derived from a… 
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