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A genome-wide view of Caenorhabditis elegans base-substitution mutation processes
Knowledge of mutation processes is central to understanding virtually all evolutionary phenomena and the underlying nature of genetic disorders and cancers. However, the limitations of standardExpand
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Mutation rate variation in multicellular eukaryotes: causes and consequences
A basic knowledge about mutation rates is central to our understanding of a myriad of evolutionary phenomena, including the maintenance of sex and rates of molecular evolution. Although there isExpand
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Variation in Base-Substitution Mutation in Experimental and Natural Lineages of Caenorhabditis Nematodes
Variation among lineages in the mutation process has the potential to impact diverse biological processes ranging from susceptibilities to genetic disease to the mode and tempo of molecularExpand
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Comparative evolutionary genetics of spontaneous mutations affecting fitness in rhabditid nematodes.
  • C. Baer, F. Shaw, +8 authors M. Lynch
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences…
  • 19 April 2005
Deleterious mutations are of fundamental importance to all aspects of organismal biology. Evolutionary geneticists have expended tremendous effort to estimate the genome-wide rate of mutation and theExpand
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Population genomics: genome-wide sampling of insect populations.
Modern population genetics underwent a major paradigm shift during the last decade of the 20th century with the discovery that thousands of genes of known function and position in a genome can beExpand
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High Rate of Large Deletions in Caenorhabditis briggsae Mitochondrial Genome Mutation Processes
Mitochondrial DNA (mtDNA) mutations underlie a variety of human genetic disorders and are associated with the aging process. mtDNA polymorphisms are widely used in a variety of evolutionaryExpand
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How and When Selection Experiments Might Actually be Useful1
Abstract Laboratory natural selection and artificial selection are vital tools for addressing specific questions about evolutionary patterns of variation. Laboratory natural selection can illuminateExpand
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Among-locus variation in Fst: fish, allozymes and the Lewontin-Krakauer test revisited.
  • C. Baer
  • Biology, Medicine
  • Genetics
  • 1 June 1999
Variation among loci in the distribution of allele frequencies among subpopulations is well known; how to tell when the variation exceeds that expected when all loci are subject to uniformExpand
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  • C. Baer, J. Travis
  • Biology, Medicine
  • Evolution; international journal of organic…
  • 1 February 2000
Abstract.— Tradeoffs in performance or fitness across environments have important implications regarding the nature of evolutionary constraints. It remains controversial whether tradeoffs such asExpand
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Cumulative Effects of Spontaneous Mutations for Fitness in Caenorhabditis: Role of Genotype, Environment and Stress
It is often assumed that the mutation rate is an evolutionarily optimized property of a taxon. The relevant mutation rate is for mutations that affect fitness, U, but the strength of selection on theExpand
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