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Mutagenesis, Site-Directed

Known as: Site-Directed Mutagenesis, Mutageneses, Site-Directed, Mutagenesis, Site Specific 
A mutation created in a gene at a specific location. Targeted mutations are frequently generated in the laboratory to investigate the influence of… 
National Institutes of Health

Related topics

Related topics

8 relations
Amino Acid SubstitutionGene ModificationMutagenesis, CassetteProtein Engineering

Narrower (1)

Oligonucleotide-Directed Mutagenesis

Broader (1)

genetic manipulation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Insertional mutagenesis identifies genes that promote the immortalization of primary bone marrow progenitor cells.
Retroviruses can induce hematopoietic disease via insertional mutagenesis of cancer genes and provide valuable molecular tags for… 
Highly Cited
2002
Highly Cited
2002
Targeted mutation of Cyln2 in the Williams syndrome critical region links CLIP-115 haploinsufficiency to neurodevelopmental abnormalities in mice
Williams syndrome is a neurodevelopmental disorder caused by the hemizygous deletion of 1.6 Mb on human chromosome 7q11.23. This… 
Highly Cited
1996
Highly Cited
1996
Targeted mutation of plakoglobin in mice reveals essential functions of desmosomes in the embryonic heart
Plakoglobin (gamma-catenin), a member of the armadillo family of proteins, is a constituent of the cytoplasmic plaque of… 
Highly Cited
1995
Highly Cited
1995
Targeted mutation in the Fas gene causes hyperplasia in peripheral lymphoid organs and liver
Fas, a type I membrane protein that transduces an apoptotic signal, is expressed in lymphocytes as well as in various tissues… 
Highly Cited
1995
Highly Cited
1995
Targeted mutation in the col5a2 gene reveals a regulatory role for type V collagen during matrix assembly
The tissue–specific organization of collagen molecules into tridimensional macroaggregates determines the physiomechanical… 
Highly Cited
1994
Highly Cited
1994
Targeted mutation of the CREB gene: compensation within the CREB/ATF family of transcription factors.
The cAMP response element binding protein (CREB) has been implicated as a key regulator in the transcriptional control of many… 
Highly Cited
1994
Highly Cited
1994
Targeted mutation in the neurotrophin-3 gene results in loss of muscle sensory neurons.
Neurotrophin 3 (NT-3) is one of four related polypeptide growth factors that share structural and functional homology to nerve… 
Highly Cited
1993
Highly Cited
1993
A selective defect in IgG2b switching as a result of targeted mutation of the I gamma 2b promoter and exon.
LPS stimulation of B lymphocytes induces germline transcription of and subsequent switching to the gamma 2b gene. Mature germline… 
Highly Cited
1988
Highly Cited
1988
Targeted mutation of the Hprt gene in mouse embryonic stem cells.
The hypoxanthine-guanine phosphoribosyltransferase (Hprt) gene has been mutated in mouse blastocyst-derived embryonic stem cells… 
Review
1987
Review
1987
Timing, Genetic Requirements and Functional Consequences of Somatic Hypermutation during B‐Cell Development
While somatic antibody mutants are rare in the preimmune repertoire and in primary immune responses, they dominate secondary and… 
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