Mutagenesis, Site-Directed

Known as: Site-Directed Mutagenesis, Mutageneses, Site-Directed, Mutagenesis, Site Specific 
A mutation created in a gene at a specific location. Targeted mutations are frequently generated in the laboratory to investigate the influence of… (More)
National Institutes of Health

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Highly Cited
2015
Highly Cited
2015
Amyotrophic lateral sclerosis (ALS) is a genetically heterogeneous neurodegenerative syndrome hallmarked by adult-onset loss of… (More)
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Highly Cited
1999
Highly Cited
1999
It is estimated that approximately 2500 genes are essential for the normal development of a zebrafish embryo. A mutation in any… (More)
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Highly Cited
1999
Highly Cited
1999
It has been proposed that the plasma phospholipid transfer protein (PLTP) facilitates the transfer of phospholipids and… (More)
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Highly Cited
1996
Highly Cited
1996
Fatty acid binding proteins (FABPs) are small cytoplasmic proteins that are expressed in a highly tissue-specific manner and bind… (More)
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Highly Cited
1996
Highly Cited
1996
Plakoglobin (gamma-catenin), a member of the armadillo family of proteins, is a constituent of the cytoplasmic plaque of… (More)
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Highly Cited
1995
Highly Cited
1995
Fas, a type I membrane protein that transduces an apoptotic signal, is expressed in lymphocytes as well as in various tissues… (More)
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Highly Cited
1994
Highly Cited
1994
The cAMP response element binding protein (CREB) has been implicated as a key regulator in the transcriptional control of many… (More)
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Highly Cited
1993
Highly Cited
1993
Krox20 is a zinc finger gene expressed in rhombomeres 3 and 5 during hindbrain development in vertebrates. Mice homozygous for a… (More)
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Highly Cited
1992
Highly Cited
1992
Gene targeting in embryonic stem (ES) cells has been used to mutate the murine DNA methyltransferase gene. ES cell lines… (More)
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Highly Cited
1992
Highly Cited
1992
We have generated mice carrying a mutation of the gene encoding the low affinity NGF receptor p75NGFR by targeted mutation in… (More)
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