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Mutagenesis, Site-Directed

Known as: Site-Directed Mutagenesis, Mutageneses, Site-Directed, Mutagenesis, Site Specific 
A mutation created in a gene at a specific location. Targeted mutations are frequently generated in the laboratory to investigate the influence of… 
National Institutes of Health

Related topics

Related topics

8 relations
Amino Acid SubstitutionGene ModificationMutagenesis, CassetteProtein Engineering

Narrower (1)

Oligonucleotide-Directed Mutagenesis

Broader (1)

genetic manipulation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2008
2008
Targeted mutation of the calbindin D28K gene disrupts circadian rhythmicity and entrainment
The suprachiasmatic nucleus (SCN) is the principal circadian pacemaker in mammals. A salient feature of the SCN is that cells of… 
2007
2007
A Natural Variant of the Heme-Binding Signature (R441C) Resulting in Complete Loss of Function of CYP2D6
A new variant allele CYP2D6*62 (g.4044C>T; R441C) of the drug-metabolizing cytochrome P450 (P450) CYP2D6 was identified in a… 
2006
2006
Nephrogenic syndrome of inappropriate antidiuresis: a novel disorder in water balance in pediatric patients.
2005
2005
Tumor model-specific proviral insertional mutagenesis of the Fos/Jdp2/Batf locus.
1999
1999
Needle-in-a-haystack detection and identification of base substitution mutations in human tissues.
Highly Cited
1998
Highly Cited
1998
Rhizobium leguminosarum contains a group of genes that appear to code for methyl-accepting chemotaxis proteins.
Methyl-accepting chemotaxis proteins (MCPs) play important roles in the chemotactic response of many bacteria. Oligonucleotide… 
Review
1998
Review
1998
The role of IL‐11 in hematopoiesis as revealed by a targeted mutation of its receptor
Interleukin 11 (IL‐11) is a pleiotropic growth factor with several actions in common with members of the IL‐6 family. IL‐11… 
1994
1994
Prediction and site-specific mutagenesis of residues in transmembrane alpha-helices of proton-pumping nicotinamide nucleotide transhydrogenases from Escherichia coli and bovine heart mitochondria.
Nicotinamide nucleotide transhydrogenase from bovine heart consists of a single polypeptide of 109 kD. The complete gene for this… 
Highly Cited
1993
Highly Cited
1993
Identification of carbohydrate structures in glycoprotein peptide maps by the use of LC/MS with selected ion extraction with special reference to tissue plasminogen activator and a glycosylation…
Electrospray ionization mass spectrometry utilizing a single quadrupole on line with reversed-phase HPLC (LC/MS) enables the… 
1985
1985
Application of the mini-Mu-phage for target-sequence-specific insertional mutagenesis of the herpes simplex virus genome.
An earlier technique for insertional mutagenesis of large viral genomes involved the insertion of the thymidine kinase (TK) gene… 
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