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Gene Modification

Known as: Editing, Gene, Gene Editing, Genetic Modification 
Genetic engineering techniques that involve DNA REPAIR mechanisms for incorporating site-specific modifications into a cell's genome.
National Institutes of Health

Related topics

Related topics

6 relations
CRISPR-Cas SystemsMutagenesis, Site-DirectedOrganism Modificationlegislation & jurisprudence

Broader (1)

Genome Editing

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
The ORF61 Protein Encoded by Simian Varicella Virus and Varicella-Zoster Virus Inhibits NF-κB Signaling by Interfering with IκBα Degradation
ABSTRACT Varicella-zoster virus (VZV) causes chickenpox upon primary infection and establishes latency in ganglia. Reactivation… 
2013
2013
A CRISPR CASe for high-throughput silencing
Manipulation of gene expression on a genome-wide level is one of the most important systematic tools in the post-genome era. Such… 
Review
2010
Review
2010
Mouse models of apnea: strain differences in apnea expression and its pharmacologic and genetic modification.
Mouse strain differences exist in post-hypoxic ventilatory behavior, specifically, the C57BL/6 J (B6) mouse exhibits irregular… 
2009
2009
Use of internally nuclease‐protected single‐strand DNA oligonucleotides and silencing of the mismatch repair protein, MSH2, enhances the replication of corrected cells following gene editing
Gene editing is potentially a powerful technology for introducing genetic changes by using short single‐stranded DNA… 
2008
2008
Sequential genetic modification of the hprt locus in human ESCs combining gene targeting and recombinase-mediated cassette exchange.
Genetic modification of human embryonic stem cells (hESCs) will be an essential tool to allow full exploitation of these cells in… 
2000
2000
Engrafting Costimulator Molecules onto Tumor Cell Surfaces with Chelator Lipids: A Potentially Convenient Approach in Cancer Vaccine Development1
The genetic modification of cells to develop cell-based vaccines and to modulate immune responses in vivo can be risky and… 
Highly Cited
1999
Highly Cited
1999
Enhanced therapeutic efficacy of tumor RNA-pulsed dendritic cells after genetic modification with lymphotactin.
Pulsing dendritic cells (DCs) with tumor cell-derived mRNA is regarded as an attractive alternative in the development of DC… 
Highly Cited
1997
Highly Cited
1997
Infection of human marrow stroma by human immunodeficiency virus-1 (HIV-1) is both required and sufficient for HIV-1-induced hematopoietic suppression in vitro: demonstration by gene modification of…
Patients with human immunodeficiency virus-1 (HIV-1) infection often present with bone marrow (BM) failure that may affect all… 
1995
1995
Cytotoxic effects of ricin without an interchain disulfide bond: genetic modification and chemical crosslinking studies.
Highly Cited
1965
Highly Cited
1965
HARTNUP DISEASE: A GENETIC MODIFICATION OF INTESTINAL AND RENAL TRANSPORT OF CERTAIN NEUTRAL ALPHA-AMINO ACIDS.
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