Gene Modification

Known as: Editing, Gene, Gene Editing, Genetic Modification 
Genetic engineering techniques that involve DNA REPAIR mechanisms for incorporating site-specific modifications into a cell's genome.
National Institutes of Health

Papers overview

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Highly Cited
2016
Highly Cited
2016
Frame-disrupting mutations in the DMD gene, encoding dystrophin, compromise myofiber integrity and drive muscle deterioration in… (More)
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Highly Cited
2015
Highly Cited
2015
The insertion of precise genetic modifications by genome editing tools such as CRISPR-Cas9 is limited by the relatively low… (More)
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Highly Cited
2015
Highly Cited
2015
Genome engineering technology offers unparalleled potential for modifying human and nonhuman genomes. In humans, it holds the… (More)
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Highly Cited
2014
Highly Cited
2014
BACKGROUND CCR5 is the major coreceptor for human immunodeficiency virus (HIV). We investigated whether site-specific… (More)
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Highly Cited
2014
Highly Cited
2014
AIDS remains incurable due to the permanent integration of HIV-1 into the host genome, imparting risk of viral reactivation even… (More)
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Highly Cited
2013
Highly Cited
2013
The type II CRISPR/Cas system from Streptococcus pyogenes and its simplified derivative, the Cas9/single guide RNA (sgRNA) system… (More)
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Highly Cited
2012
Highly Cited
2012
volume 30 number 5 may 2012 nature biotechnology 24 repeat units for recognition of a specific set of 24 contiguous nucleotides… (More)
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Highly Cited
2008
Highly Cited
2008
Custom-made zinc-finger nucleases (ZFNs) can induce targeted genome modifications with high efficiency in cell types including… (More)
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Highly Cited
2007
Highly Cited
2007
Achieving the full potential of zinc-finger nucleases (ZFNs) for genome engineering in human cells requires their efficient… (More)
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Highly Cited
2002
Highly Cited
2002
Somatic gene transfer is a promising therapeutic strategy, but it may also evoke new types of side effects related to genetic… (More)
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