Amino Acid Substitution

Known as: Amino Acid Substitutions, Substitution, Amino Acid, Substitutions, Amino Acid 
The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent… (More)
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
As next-generation sequencing projects generate massive genome-wide sequence variation data, bioinformatics tools are being… (More)
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Highly Cited
2009
Highly Cited
2009
The effect of genetic mutation on phenotype is of significant interest in genetics. The type of genetic mutation that causes a… (More)
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Highly Cited
2009
Highly Cited
2009
MOTIVATION Advances in high-throughput genotyping and next generation sequencing have generated a vast amount of human genetic… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Most patients with non-small-cell lung cancer have no response to the tyrosine kinase inhibitor gefitinib, which… (More)
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Highly Cited
2003
Highly Cited
2003
Single nucleotide polymorphism (SNP) studies and random mutagenesis projects identify amino acid substitutions in protein-coding… (More)
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Highly Cited
2001
Highly Cited
2001
Many missense substitutions are identified in single nucleotide polymorphism (SNP) data and large-scale random mutagenesis… (More)
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Highly Cited
1998
Highly Cited
1998
The removal or repair of DNA damage has a key role in protecting the genome of the cell from the insults of cancer-causing agents… (More)
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Highly Cited
1994
Highly Cited
1994
The sensitivity of the commonly used progressive multiple sequence alignment method has been greatly improved for the alignment… (More)
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Highly Cited
1992
Highly Cited
1992
Methods for alignment of protein sequences typically measure similarity by using a substitution matrix with scores for all… (More)
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Highly Cited
1991
Highly Cited
1991
Protein sequence alignments have become an important tool for molecular biologists. Local alignments are frequently constructed… (More)
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