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Amino Acid Substitution

Known as: Amino Acid Substitutions, Substitution, Amino Acid, Substitutions, Amino Acid 
The naturally occurring or experimentally induced replacement of one or more AMINO ACIDS in a protein with another. If a functionally equivalent… 
National Institutes of Health

Papers overview

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Highly Cited
2015
Highly Cited
2015
UNLABELLED We present a web server to predict the functional effect of single or multiple amino acid substitutions, insertions… 
Highly Cited
2012
Highly Cited
2012
As next-generation sequencing projects generate massive genome-wide sequence variation data, bioinformatics tools are being… 
Highly Cited
2012
Highly Cited
2012
The Sorting Intolerant from Tolerant (SIFT) algorithm predicts the effect of coding variants on protein function. It was first… 
Highly Cited
2004
Highly Cited
2004
BACKGROUND Most patients with non-small-cell lung cancer have no response to the tyrosine kinase inhibitor gefitinib, which… 
Highly Cited
2003
Highly Cited
2003
Single nucleotide polymorphism (SNP) studies and random mutagenesis projects identify amino acid substitutions in protein-coding… 
Highly Cited
2001
Highly Cited
2001
Many missense substitutions are identified in single nucleotide polymorphism (SNP) data and large-scale random mutagenesis… 
Highly Cited
1998
Highly Cited
1998
The removal or repair of DNA damage has a key role in protecting the genome of the cell from the insults of cancer-causing agents… 
Highly Cited
1994
Highly Cited
1994
The sensitivity of the commonly used progressive multiple sequence alignment method has been greatly improved for the alignment… 
Highly Cited
1992
Highly Cited
1992
Methods for alignment of protein sequences typically measure similarity by using a substitution matrix with scores for all… 
Highly Cited
1981
Highly Cited
1981
  • T. Hopp, K. R. Woods
  • Proceedings of the National Academy of Sciences…
  • 1981
  • Corpus ID: 677016
A method is presented for locating protein antigenic determinants by analyzing amino acid sequences in order to find the point of…