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Mitoxantrone

Known as: 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthroquinone, 1,4-DIHYDROXY-5,8-bis({2-[(2-hydroxyethyl)amino]ethyl}amino)-9,10-anthracenedione, Mitoxantronum 
An anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA… 
National Institutes of Health

Related topics

Related topics

49 relations

Broader (2)

Antineoplastic Agentsanthracene

Narrower (26)

BBR 2577BBR3378CL 232315DMV regimen
Congestive heart failureIn BloodMammary NeoplasmsMitoxantrone Hydrochloride

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2005
Highly Cited
2005
Investigation of Efflux Transport of Dehydroepiandrosterone Sulfate and Mitoxantrone at the Mouse Blood-Brain Barrier: A Minor Role of Breast Cancer Resistance Protein
Breast cancer resistance protein (Bcrp/Abcg2) is a new efflux transporter found at the blood-brain barrier (BBB) of humans and… 
Review
2002
Review
2002
A study of therapy-related acute leukaemia after mitoxantrone therapy for multiple sclerosis
To evaluate the incidence of therapy-related acute leukaemia (t-AL) after single-agent mitoxantrone (MITO) treatment, we reviewed… 
Highly Cited
2000
Highly Cited
2000
Adjuvant mitozantrone chemotherapy in advanced prostate cancer
Objective To assess the role of mitozantrone, active in relapsed prostate cancer, as an adjuvant to hormonal treatment in… 
Highly Cited
2000
Highly Cited
2000
Methotrexate cross-resistance in a mitoxantrone-selected multidrug-resistant MCF7 breast cancer cell line is attributable to enhanced energy-dependent drug efflux.
Cellular resistance to the antifolate methotrexate (MTX) is often caused by target amplification, uptake defects, or alterations… 
Highly Cited
2000
Highly Cited
2000
Inhibition of topoisomerase II by the marine alkaloid ascididemin and induction of apoptosis in leukemia cells.
Highly Cited
1996
Highly Cited
1996
Combination of quinine as a potential reversing agent with mitoxantrone and cytarabine for the treatment of acute leukemias: a randomized multicenter study.
A phase III prospective randomized multicenter study was performed to determine whether quinine could improve the response rate… 
Highly Cited
1995
Highly Cited
1995
Biochemical and molecular characterization of the oxidative branch of glycerol utilization by Citrobacter freundii
Glycerol dehydrogenase (EC 1.1.1.6) and dihydroxyacetone kinase (EC 2.7.1.29) were purified from Citrobacter freundii. The… 
Highly Cited
1993
Highly Cited
1993
Topoisomerase II alpha co-amplification with erbB2 in human primary breast cancer and breast cancer cell lines: relationship to m-AMSA and mitoxantrone sensitivity.
Topoisomerase II alpha (topo II alpha) is a key enzyme in DNA replication and a target for many anti-cancer drugs. High levels… 
Highly Cited
1990
Highly Cited
1990
Membrane vesicle formation due to acquired mitoxantrone resistance in human gastric carcinoma cell line EPG85-257.
A newly established gastric carcinoma cell line (EPG85-257P) exhibited a high sensitivity to mitoxantrone (DHAD) as determined by… 
Review
1983
Review
1983
The design, synthesis and development of a new class of potent antineoplastic anthraquinones.
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