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Mitoxantrone
Known as:
1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthroquinone
, 1,4-DIHYDROXY-5,8-bis({2-[(2-hydroxyethyl)amino]ethyl}amino)-9,10-anthracenedione
, Mitoxantronum
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An anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA…
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National Institutes of Health
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Related topics
Related topics
49 relations
Broader (2)
Antineoplastic Agents
anthracene
Narrower (26)
BBR 2577
BBR3378
CL 232315
DMV regimen
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Congestive heart failure
In Blood
Mammary Neoplasms
Mitoxantrone Hydrochloride
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2005
Review
2005
Mitoxantrone in the treatment of multiple sclerosis.
Morrissey Sp
,
E. Lepage
,
G. Edan
International MS journal
2005
Corpus ID: 19148381
Mitoxantrone is useful for the treatment of cancer and MS and, as with other chemotherapeutic agents, many studies have examined…
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2002
2002
Excess Electron Transfer in DNA: Effect of Base Sequence and Proton Transfer
Zhongli Cai
,
Xifeng Li
,
M. Sevilla
2002
Corpus ID: 38456076
The effect of base sequence on excess electron transfer (ET) along the DNA “π-way" is investigated in this work by use of various…
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1996
1996
Interstitial chemotherapy with mitoxantrone in recurrent malignant glioma: preliminary data
A. Boiardi
,
A. Salmaggi
,
A. Pozzi
,
G. Broggi
,
A. Silvani
Journal of Neuro-Oncology
1996
Corpus ID: 6732545
SummaryWe undertook a phase I-II trial of loco-regional mitoxantrone in 12 patients affected by malignant gliomas. Mitoxantrone…
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1994
1994
Effects of amiodarone, cyclosporin A, and PSC 833 on the cytotoxicity of mitoxantrone, doxorubicin, and vincristine in non-P-glycoprotein human small cell lung cancer cell lines.
Wta Vandergraaf
,
Ege Devries
,
+4 authors
N. Mulder
Cancer Research
1994
Corpus ID: 7529411
The multidrug resistance (MDR) modulators amiodarone (AM), cyclosporin A (CsA), and PSC 833 were tested for their potential to…
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Highly Cited
1984
Highly Cited
1984
Clinical safety and tolerance of mitoxantrone.
Cross Rj
1984
Corpus ID: 77870211
: Mitoxantrone has been administered to more than 4000 patients worldwide. From this data base, a summary of the latest…
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1984
1984
Mitoxantrone in relapsed and refractory acute leukemia.
H. Prentice
,
G. Robbins
,
D. Ma
,
A. Ho
Seminars in Oncology
1984
Corpus ID: 10658428
Mitoxantrone is a relatively new synthetic anthracenedione derivative with intercalating properties. An in vitro study with…
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1983
1983
Effect of temperature on the cytotoxicity of vindesine, amsacrine, and mitoxantrone.
Herman Ts
1983
Corpus ID: 100526658
: The effect of elevated temperature on the cytotoxicity of three new anticancer drugs (vindesine, mitoxantrone, and amsacrine…
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1982
1982
Comparison of the effects of dihydroxyanthraquinone and adriamycin on the survival of cultured Chinese hamster cells.
B. Kimler
,
C. Cheng
Cancer Research
1982
Corpus ID: 17861731
Dihydroxyanthraquinone [1,4-dihydroxy-5,8-bis ((2-([(2-hydroxyethyl)amino)ethyl)amino))-9,10-anthracenedione (DHAQ) (NSC 279836…
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1982
1982
Phase I study of a 5-day schedule of mitoxantrone (dihydroxyanthracenedione).
W. R. Wynert
,
H. Harvey
,
A. Lipton
,
J. Schweitzer
,
D. White
Cancer treatment reports
1982
Corpus ID: 26928289
Mitoxantrone (1,4-dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9,10-anthracenedione dihydrochloride) in animal…
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1980
1980
Effect of dihydroxyanthraquinone and radiation on G2 progression.
B. Kimler
Cancer Research
1980
Corpus ID: 38708025
The effect of dihydroxyanthraquinone (DHAQ), a potential anticancer chemotherapeutic agent, on the progression of Chinese hamster…
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