Mitoxantrone

Known as: 1,4-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthroquinone, 1,4-DIHYDROXY-5,8-bis({2-[(2-hydroxyethyl)amino]ethyl}amino)-9,10-anthracenedione, Mitoxantronum 
An anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby disrupting DNA and RNA… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1975-2018
010020019752018

Papers overview

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Highly Cited
2010
Highly Cited
2010
Royal Marsden NHS Foundation Trust and The Institute of Cancer Research, Sutton, UK (J S de Bono FRCP); Tulane University, New… (More)
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Highly Cited
2008
Highly Cited
2008
PURPOSE The TAX 327 study compared docetaxel administered every 3 weeks (D3), weekly docetaxel (D1), and mitoxantrone (M), each… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Mitoxantrone plus prednisone reduces pain and improves the quality of life in men with advanced, hormone-refractory… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND Mitoxantrone-based chemotherapy palliates pain without extending survival in men with progressive androgen-independent… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND Treatment options for patients with secondary progressive multiple sclerosis are few. Encouraging results in open… (More)
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Highly Cited
2002
Highly Cited
2002
Hematopoietic stem cells (HSCs) can be identified by a "side population" (SP) phenotype. Previous studies have implicated the ATP… (More)
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Highly Cited
1999
Highly Cited
1999
Reports of multiple distinct mitoxantrone-resistant sublines without overexpression of P-glycoprotein or the multidrug-resistance… (More)
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Highly Cited
1999
Highly Cited
1999
BACKGROUND Human cancer cell lines grown in the presence of the cytotoxic agent mitoxantrone frequently develop resistance… (More)
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Highly Cited
1999
Highly Cited
1999
Mouse fibroblast cell lines lacking functional Mdr1a, Mdr1b, and Mrp1 genes were selected for resistance to topotecan… (More)
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Highly Cited
1996
Highly Cited
1996
PURPOSE To investigate the benefit of chemotherapy in patients with symptomatic hormone-resistant prostate cancer using relevant… (More)
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