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Mitoxantrone Hydrochloride

Known as: 1,3-Dihydroxy-5,8-bis[[2-[(2-hydroxyethyl)amino]ethyl]amino]-9, 10-anthracenedione Dihydrochloride, Mitoxantrone Dihydrochloride, Mitozantrone Hydrochloride 
The hydrochloride salt of an anthracenedione antibiotic with antineoplastic activity. Mitoxantrone intercalates into and crosslinks DNA, thereby… Expand
National Institutes of Health

Related topics

Related topics

38 relations

Narrower (4)

CL 232315NSC-301739NovantroneOnkotrone
CNOP RegimenCongestive heart failureEtoposide/Ifosfamide/Mesna/MitoxantroneFMC protocol
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Broader (1)

Mitoxantrone

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2014
Highly Cited
2014
Initial biopsy Gleason score as a predictive marker for survival benefit in patients with castration-resistant prostate cancer treated with docetaxel: data from the TAX327 study.
BACKGROUND Since 2004, docetaxel has been the standard first-line systemic therapy for patients with metastatic castration… Expand
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Highly Cited
2011
Highly Cited
2011
Cytarabine dose for acute myeloid leukemia.
BACKGROUND Cytarabine (ara-C) is an important drug in the treatment of acute myeloid leukemia (AML). High-dose cytarabine (2000… Expand
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Highly Cited
2011
Highly Cited
2011
Cytarabine dose for acute myeloid leukemia.
The authors reply: Shukla correctly notes that smokeless tobacco use is common among Indians and Bangladeshis. Because habitual… Expand
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Highly Cited
2006
Highly Cited
2006
Study of mitoxantrone for the treatment of recurrent neuromyelitis optica (Devic disease).
BACKGROUND Neuromyelitis optica is a severe demyelinating disease that selectively involves the optic nerves and the spinal cord… Expand
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Highly Cited
2001
Highly Cited
2001
Attempts to improve treatment outcomes in acute myeloid leukemia (AML) in older patients: the results of the United Kingdom Medical Research Council AML11 trial.
In an attempt to improve induction chemotherapy for older patients with acute myeloid leukemia (AML),1314 patients were… Expand
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Highly Cited
2000
Highly Cited
2000
Safety of fludarabine, mitoxantrone, and dexamethasone combined with rituximab in the treatment of stage IV indolent lymphoma.
Rituximab (Rituxan; Genentech, Inc, South San Francisco, CA and IDEC Pharmaceutical Corporation, San Diego, CA) is an effective… Expand
Highly Cited
1999
Highly Cited
1999
Camptothecin resistance: role of the ATP-binding cassette (ABC), mitoxantrone-resistance half-transporter (MXR), and potential for glucuronidation in MXR-expressing cells.
The mitoxantrone resistance (MXR) gene encodes a recently characterized ATP-binding cassette half-transporter that confers… Expand
Highly Cited
1996
Highly Cited
1996
Prednimustine, mitoxantrone (PmM) vs cyclophosphamide, vincristine, prednisone (COP) for the treatment of advanced low-grade non-Hodgkin's lymphoma. German Low-Grade Lymphoma Study Group.
The current study was initiated to compare the anti-lymphoma activity and side-effects of prednimustine/mitoxantrone (PmM) vs… Expand
Highly Cited
1986
Highly Cited
1986
Selective immunomodulation by the antineoplastic agent mitoxantrone. I. Suppression of B lymphocyte function.
Novantrone mitoxantrone, an antineoplastic agent with antiproliferative properties, is under investigation as an immunomodulating… Expand
Highly Cited
1983
Highly Cited
1983
Mitoxantrone in patients with acute leukemia in relapse.
Twenty-six patients with acute leukemia in relapse were treated with mitoxantrone (dihydroxyanthracenedione dihydrochloride). The… Expand
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