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Mitogen-Activated Protein Kinase 4, human

Known as: MAPK 4, ERK-4, MAPK4 
Mitogen-activated protein kinase 4 (587 aa, ~66 kDa) is encoded by the human MAPK4 gene. This protein is involved in serine/threonine phosphorylation… 
National Institutes of Health

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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
MAPK4 deletion enhances radiation effects and triggers synergistic lethality with simultaneous PARP1 inhibition in cervical cancer
Background Cervical cancer is one of the most common cancers among females worldwide and advanced patients have extremely poor… 
Highly Cited
2019
Highly Cited
2019
MAPK4 overexpression promotes tumor progression via noncanonical activation of AKT/mTOR signaling
MAPK4 is an atypical MAPK. Currently, little is known about its physiological function and involvement in diseases, including… 
2019
2019
MPK4 Phosphorylation Dynamics and Interacting Proteins in Plant Immunity.
Arabidopsis MAP kinase 4 (MPK4) has been proposed to be a negative player in plant immunity, and it is also activated by pathogen… 
Highly Cited
2013
Highly Cited
2013
The Tumor Suppressor Roles of miR-433 and miR-127 in Gastric Cancer
The discovery of microRNAs (miRNAs) provides a new and powerful tool for studying the mechanism, diagnosis and treatment of human… 
Highly Cited
2010
Highly Cited
2010
Pseudomonas syringae effector protein AvrB perturbs Arabidopsis hormone signaling by activating MAP kinase 4.
Highly Cited
2010
Highly Cited
2010
Arabidopsis MKS1 Is Involved in Basal Immunity and Requires an Intact N-terminal Domain for Proper Function
Background Innate immune signaling pathways in animals and plants are regulated by mitogen-activated protein kinase (MAPK… 
2009
2009
Profiling of transcripts and proteins modulated by K-ras oncogene in the lung tissues of K-ras transgenic mice by omics approaches.
The mutated K-ras gene is involved in approximately 30% of human cancers. In order to search for K-ras oncogene-induced… 
2007
2007
Phosphorylation sites of Arabidopsis MAP kinase substrate 1 (MKS1).
1997
1997
Differential Tyrosyl-Phosphorylation of Multiple Mitogen-activated Protein Kinase Isoforms in Response to Prolactin in Nb2 Lymphoma Cells
Abstract Prolactin (PRL) stimulates mitogenesis and differentiative processes in a variety of cell types. Not all of the… 
Highly Cited
1995
Highly Cited
1995
The signal transduction pathway of erythropoietin involves three forms of mitogen-activated protein (MAP) kinase in UT7 erythroleukemia cells.
The survival and proliferation of the UT-7 human leukemic cell line is strictly dependent on the presence of either interleukin 3… 
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