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Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos
TLDR
By coinjection of Cas9 mRNA and sgRNAs into one-cell-stage embryos, this system successfully achieves precise gene targeting in cynomolgus monkeys and enables simultaneous disruption of two target genes in one step, and no off-target mutagenesis was detected by comprehensive analysis.
Arabidopsis homolog of the yeast TREX-2 mRNA export complex: components and anchoring nucleoporin.
TLDR
Physical and functional evidence support the identification of the Arabidopsis orthologs of yeast Thp1 and Nup1 as putative TREX-2 components and provides a foundation for future studies of nuclear export inArabidopsis.
Heterogeneous Face Attribute Estimation: A Deep Multi-Task Learning Approach
TLDR
This paper presents a Deep Multi-Task Learning (DMTL) approach to jointly estimate multiple heterogeneous attributes from a single face image, and introduces an unconstrained face database (LFW+), an extension of public-domain LFW, with heterogeneous demographic attributes obtained via crowdsourcing.
Organochlorine pesticides in soils under different land usage in the Taihu Lake region, China.
TLDR
The data show that the ban on the use of HCH and DDT resulted in a tremendous reduction of these pesticide residues in soils, but there are still high amounts of pesticide residuesIn soils, which need more remediation processes.
Soybean NAC transcription factors promote abiotic stress tolerance and lateral root formation in transgenic plants.
TLDR
The roles of the two GmNAC genes in stress tolerance were further analyzed in soybean transgenic hairy roots and provide a basis for genetic manipulation to improve the agronomic traits of important crops.
Location matters: site of conjugation modulates stability and pharmacokinetics of antibody drug conjugates.
TLDR
It is shown that the conjugation site has significant impact on ADC stability and pharmacokinetics in a species-dependent manner and can be directly attributed to the position of the linkage rather than the chemical instability, as was observed with a maleimide linkage.
Bioproducts from Aureobasidium pullulans, a biotechnologically important yeast
TLDR
It is very important to sequence the whole genomic DNA of the yeast cells in order to find new more bioproducts and novel genes from this yeast.
Comprehensive Characterization of Cancer Driver Genes and Mutations
TLDR
The MC3 Working Group, The Cancer Genome Atlas Research Network, Michael S. Lawrence, Adam Godzik, Nuria Lopez-Bigas, Josh Stuart, David Wheeler, Gad Getz, Ken Chen, Alexander J. Lazar, Gordon B. Mills, Rachel Karchin, Li Ding are the authors of this paper.
Molecular Mechanism of microRNA396 Mediating Pistil Development in Arabidopsis1[W]
TLDR
An important role for miR396 is revealed in controlling carpel number and pistil development via regulation of the GRF/GIF complex.
Physiological and Transcriptome Analysis of Iron and Phosphorus Interaction in Rice Seedlings1[C][W]
TLDR
Evidence is provided that the presence of P can affect Fe availability and in turn can influence the regulation of Fe-responsive genes.
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