Profiling of transcripts and proteins modulated by K-ras oncogene in the lung tissues of K-ras transgenic mice by omics approaches.

@article{Lee1992ProfilingOT,
  title={Profiling of transcripts and proteins modulated by K-ras oncogene in the lung tissues of K-ras transgenic mice by omics approaches.},
  author={Sojung Lee and Jungwoo Kang and Minchul Cho and Eunhee Seo and Heesook Choi and EunJin Kim and Junghee J. Kim and Heejong Kim and Gum Yong Kang and Kwang Pyo Kim and Young-Ho Park and dAE-yEUL yU and Young Na Yum and Sue-Nie Park and Do-Young Yoon},
  journal={International journal of oncology},
  year={1992},
  volume={34 1},
  pages={
          161-72
        }
}
The mutated K-ras gene is involved in approximately 30% of human cancers. In order to search for K-ras oncogene-induced modulators in lung tissues of K-ras transgenic mice, we performed microarray and proteomics (LC/ESI-MS/MS) analysis. Genes (RAB27b RAS family, IL-1RA, IL-33, chemokine ligand 6, epiregulin, EGF-like domain and cathepsin) related to cancer development (Wnt signaling pathway) and inflammation (chemokine/cytokine signaling pathway, Toll receptor signaling) were up-regulated while… CONTINUE READING

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