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Irrespective of the morphological features of end-stage cell death (that may be apoptotic, necrotic, autophagic, or mitotic… Expand The tumor suppressor p53 exerts its anti-neoplastic activity primarily through the induction of apoptosis. We found that… Expand Bcl-2 family proteins regulate the release of proteins like cytochrome c from mitochondria during apoptosis. We used cell-free… Expand Mitochondria have been described as "the powerhouses of the cell" because they link the energy-releasing activities of electron… Expand ABSTRACT In many types of apoptosis, the proapoptotic protein Bax undergoes a change in conformation at the level of the… Expand We investigated the use of rhodamine 123 (R123), tetramethylrhodamine methyl ester (TMRM), and tetramethylrhodamine ethyl ester… Expand We report here that BID, a BH3 domain-containing proapoptotic Bcl2 family member, is a specific proximal substrate of Casp8 in… Expand Both physiological cell death (apoptosis) and, in some cases, accidental cell death (necrosis) involve a two-step process. At a… Expand We argue for the critical role of oxidative damage in causing the mitochondrial dysfunction of aging. Oxidants generated by… Expand By using a potential-dependent J-aggregate-forming delocalized lipophilic cation, 5,5',6,6'-tetrachloro-1,1',3,3… Expand