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YC-1 inhibits HIF-1 expression in prostate cancer cells: contribution of Akt/NF-kappaB signaling to HIF-1alpha accumulation during hypoxia.
TLDR
YC-1 is a novel antitumor agent that inhibits HIF-1 through previously unexplained mechanisms and is found to suppress the PI3K/Akt/mTOR/4E-BP pathway, which serves to regulate Hif-1alpha expression at the translational step.
Targeting Energy Metabolic and Oncogenic Signaling Pathways in Triple-negative Breast Cancer by a Novel Adenosine Monophosphate-activated Protein Kinase (AMPK) Activator*
TLDR
OSU-53 is a potent, orally bioavailable AMPK activator that acts through a broad spectrum of antitumor activities downstream of AMPK activation and modulated relevant intratumoral biomarkers of drug activity.
YC-1 inhibits HIF-1 expression in prostate cancer cells: contribution of Akt/NF-κB signaling to HIF-1α accumulation during hypoxia
TLDR
YC-1 is a novel antitumor agent that inhibits HIF-1 through previously unexplained mechanisms, and is found to suppress the PI3K/Akt/mTOR/4E-BP pathway, which serves to regulate Hif-1α expression at the translational step.
Antiplatelet Effect of Gingerol Isolated from Zingiber officinale
The purpose of this investigation was to determine the antiplatelet mechanism of gingerol.
Development of novel adenosine monophosphate-activated protein kinase activators.
TLDR
Evidence indicates that this drug-induced suppression of LPS-stimulated IL-6 production was attributable to AMPK activation, and compound 53-mediated AM PK activation was demonstrated in C-26 colon adenocarcinoma cells, indicating that it is not a cell line-specific event.
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