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Microtubule-Associated Proteins 1A/1B Light Chain 3

Known as: Autophagy-Related Protein Lc3, Autophagy-Related Ubiquitin-Like Modifier LC3, MAP1LC3 
A protein family whose members bind to microtubule-associated protein 1A and 1B and are involved in the formation of autophagosomes.
National Institutes of Health

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AutophagyMAP1LC3A geneMAP1LC3A wt AlleleMicrotubule-Associated Proteins 1A/1B Light Chain 3A

Papers overview

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2019
2019
PTEN-mediated mitophagy and APE 1 overexpression protects against cardiac hypoxia / reoxygenation injury
Autophagy plays a critical role in cardiac hypoxia/reoxygenation (H/R). Studies indicated that the phosphatase and tensin homolog… 
2017
2017
[Effect of Xinfeng Capsule on Beclin1/PI3K-AKT-mTOR of Adjuvant Arthritis Rats].
Objective To observe expression levels of autophagy related 5,7,12 mRNA (Atg5, 7,12), microtubule-associated protein 1 light… 
2016
2016
Hydroxycamptothecin shows antitumor efficacy on HeLa cells via autophagy activation mediated apoptosis in cervical cancer.
OBJECTIVES To investigate the effect and the mechanism of anti-tumor agent hydroxycamptothecin (HCPT) on HeLa cells in cervical… 
2016
2016
Abstract 3532: Compound Tc inhibits ATG4 to attenuate autophagic flux and sensitize cancer cells to chemotherapy
Autophagy is induced to protect cancer cells against stresses, including starvation, hypoxia and chemotherapy. Antimalarial drugs… 
2015
2015
[Molecular mechanism of emodin on inhibiting autophagy induced by HBSS in renal tubular cells].
OBJECTIVE To explore the regulative effects and possible mechanisms of emodin on autophagy induced by starvation in rat's renal… 
2014
2014
Enhanced Autophagy by Everolimus Contributes to the Antirestenotic Mechanisms in Vascular Smooth Muscle Cells
Objective: The present study aims to investigate the underlying mechanisms accounting for the activities of everolimus to inhibit… 
2013
2013
A sensitive and quantitative autolysosome probe for detecting autophagic activity in live and prestained fixed cells
Autophagy is a complex, multi-step and biologically important pathway mediated by autophagosomes and autolysosomes. Accurately… 
2013
2013
Baicalin AKT serine / threonine protein kinase modulates baicalin-triggered autophagy in human bladder cancer T 24 cells
Baicalin is one of the major compounds in the traditional Chinese medicinal herb from Scutellaria baicalensis Georgi. We… 
2011
2011
Thapsigargin-induced Sequential Expression of Proteins Related to Autophagy and Apoptosis in Human Breast Cancer MCF-7 Cells
E-mail: hwan@krict.re.krReceived May 20, 2011, Accepted July 11, 2011Key Words : Thapsigargin, Autophagy, Apoptosis, Cell death… 
2011
2011
Abstract 5589: An aqueous extract of Allspice (berries of Pimenta dioica) inhibits breast cancer growth through autophagy by targeting the estrogen receptor
Proceedings: AACR 102nd Annual Meeting 2011‐‐ Apr 2‐6, 2011; Orlando, FL Background: Breast cancer (BrCa) ranks second as cause…