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Microtubule-Associated Proteins 1A/1B Light Chain 3

Known as: Autophagy-Related Protein Lc3, Autophagy-Related Ubiquitin-Like Modifier LC3, MAP1LC3 
A protein family whose members bind to microtubule-associated protein 1A and 1B and are involved in the formation of autophagosomes.
National Institutes of Health

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Related topics

4 relations
AutophagyMAP1LC3A geneMAP1LC3A wt AlleleMicrotubule-Associated Proteins 1A/1B Light Chain 3A

Papers overview

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Highly Cited
2017
Highly Cited
2017
Autophagy Is Required for Activation of Pancreatic Stellate Cells, Associated With Pancreatic Cancer Progression and Promotes Growth of Pancreatic Tumors in Mice.
BACKGROUND & AIMS Pancreatic stellate cells (PSCs) change from a quiescent to activated state in the tumor environment and… 
Highly Cited
2015
Highly Cited
2015
V-ATPase and osmotic imbalances activate endolysosomal LC3 lipidation
Recently a noncanonical activity of autophagy proteins has been discovered that targets lipidation of microtubule-associated… 
Highly Cited
2015
Highly Cited
2015
The Relationship of Autophagy Defects to Cartilage Damage During Joint Aging in a Mouse Model
Aging is a main risk factor for osteo arthritis (OA), the most prevalent musculoskeletal disorder. Defects in autophagy, an… 
Highly Cited
2013
Highly Cited
2013
Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy
Significance β-Amyloid aggregates are often found in the brains of Alzheimer’s patients. We have previously reported that… 
Highly Cited
2012
Highly Cited
2012
Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy
Mechanisms by which autophagy promotes cell survival or death are unclear. We provide evidence that C18-pyridinium ceramide (C18… 
Highly Cited
2012
Highly Cited
2012
Paraptosis accompanied by autophagy and apoptosis was induced by celastrol, a natural compound with influence on proteasome, ER stress and Hsp90
In the present study, we found that celastrol, a natural compound with well‐known apoptosis‐inducing effect, could also induce… 
Highly Cited
2012
Highly Cited
2012
Resveratrol induces apoptosis via ROS-triggered autophagy in human colon cancer cells
Resveratrol (Res; 3,4′,5-trihydroxy-trans-stilbene), which is a polyphenol found in grapes, can block cell proliferation and… 
Highly Cited
2011
Highly Cited
2011
Autophagy is involved in traumatic brain injury-induced cell death and contributes to functional outcome deficits in mice
Highly Cited
2009
Highly Cited
2009
Enhancement of autophagic flux after neonatal cerebral hypoxia-ischemia and its region-specific relationship to apoptotic mechanisms.
The multiplicity of cell death mechanisms induced by neonatal hypoxia-ischemia makes neuroprotective treatment against neonatal… 
Highly Cited
2003
Highly Cited
2003
Post-translational Modifications of Three Members of the Human MAP1LC3 Family and Detection of a Novel Type of Modification for MAP1LC3B*
The molecular machinery required for autophagy is highly conserved in all eukaryotes as seen by the high degree of conservation… 
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