Microprocessor Complex Subunit DGCR8

Known as: DiGeorge Syndrome Critical Region 8 
Microprocessor complex subunit DGCR8 (773 aa, ~86 kDa) is encoded by the human DGCR8 gene. This protein plays a role in the maturation of microRNA.
National Institutes of Health

Topic mentions per year

Topic mentions per year

2010-2016
01220102016

Papers overview

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2017
2017
Both microRNAs (miRNAs) and endogenous small interfering RNAs (endo-siRNAs) play key regulatory roles in gene expression. Some… (More)
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2017
2017
Age-related macular degeneration (AMD) is a major cause of irreversible vision loss. The neovascular or "wet" form of AMD can be… (More)
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2016
2016
High-throughput experimental studies have indicated that the miRNAome is globally downregulated in various types of malignancy… (More)
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2016
2016
Non-coding RNAs have gained increasing attention during the last decade. The first large group of non-coding RNAs to be… (More)
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Highly Cited
2014
Highly Cited
2014
Loss- and gain-of-function mutations of the X-linked gene MECP2 (methyl-CpG binding protein 2) lead to severe neurodevelopmental… (More)
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2013
2013
MicroRNA (miRNA) biogenesis follows a conserved succession of processing steps, beginning with the recognition and liberation of… (More)
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Highly Cited
2013
Highly Cited
2013
MicroRNAs (miRNAs) regulate cardiovascular biology and disease, but the role of flow-sensitive microRNAs in atherosclerosis is… (More)
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2012
2012
DiGeorge Critical Region 8 (DGCR8) is a double-stranded RNA-binding protein that interacts with Drosha and facilitates microRNA… (More)
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Highly Cited
2010
Highly Cited
2010
MicroRNAs (miRNAs) are small noncoding RNAs that have recently emerged as critical regulators of gene expression within the… (More)
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2010
2010
BACKGROUND Drosha is a nuclear RNase III enzyme that initiates processing of regulatory microRNA. Together with partner protein… (More)
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