DGCR8 gene

Known as: Gy1, DGCRK6, DGCR8 Microprocessor Complex Subunit Gene 
This gene plays a role in microRNA processing.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1989-2018
0204019892018

Papers overview

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Review
2015
Review
2015
MicroRNAs (miRs) are a class of small noncoding RNAs that suppress the expression of protein-coding genes by repressing protein… (More)
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Highly Cited
2012
Highly Cited
2012
The Drosha–DGCR8 complex (Microprocessor) is required for microRNA (miRNA) biogenesis. DGCR8 recognizes the RNA substrate… (More)
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Highly Cited
2009
Highly Cited
2009
The Drosha-DGCR8 complex, also known as Microprocessor, is essential for microRNA (miRNA) maturation. Drosha functions as the… (More)
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Highly Cited
2009
Highly Cited
2009
MicroRNAs play important roles in animal development. Numerous conditional knockout (cKO) studies of Dicer have been performed to… (More)
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Highly Cited
2008
Highly Cited
2008
Canonical microRNAs (miRNAs) require two processing steps: the first by the Microprocessor, a complex of DGCR8 and Drosha, and… (More)
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Highly Cited
2007
Highly Cited
2007
The molecular controls that govern the differentiation of embryonic stem (ES) cells remain poorly understood. DGCR8 is an RNA… (More)
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Highly Cited
2006
Highly Cited
2006
The Drosha-DGCR8 complex initiates microRNA maturation by precise cleavage of the stem loops that are embedded in primary… (More)
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Highly Cited
2006
Highly Cited
2006
DGCR8/Pasha is an essential cofactor for Drosha, a nuclear RNase III that cleaves the local hairpin structures embedded in long… (More)
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Highly Cited
2004
Highly Cited
2004
RNase III proteins play key roles in microRNA (miRNA) biogenesis. The nuclear RNase III Drosha cleaves primary miRNAs (pri-miRNAs… (More)
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Highly Cited
2004
Highly Cited
2004
MicroRNAs (miRNAs) are a growing family of small non-protein-coding regulatory genes that regulate the expression of homologous… (More)
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