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Mexiletine Hydrochloride

Known as: Mexiletine Hydrochloride [Chemical/Ingredient], 1-Methyl-2-(2,6-xylyloxy)ethylamine Hydrochloride, mexiletine hcl 
The hydrochloride salt form of mexiletine, a local anesthetic and antiarrhythmic (Class IB) agent structurally related to lidocaine. Mexiletine… 
National Institutes of Health

Related topics

Related topics

12 relations
Anti-Arrhythmia AgentsCYP1A2 protein, humanCytochrome P450 2D6, humanDiabetic Neuropathies

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KO-1173Mexitil

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Mexiletine

Papers overview

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2004
2004
Comparison of classical and derivative UV-spectrophotometric methods for the quantification of diltiazem and mexiletine.
A first order derivative UV-spectrophotometric method for the determination of diltiazem hydrochloride and mexiletine… 
2001
2001
Acute exanthematous pustular drug eruption induced by mexiletine.
A 56-year-old man developed infiltrated erythemas on the trunk, extremities, and face with marked facial edema, one month after… 
1999
1999
Stereoselective disposition of the antiarrhythmic agent mexiletine during the concomitant administration of caffeine.
Caffeine consumption is extensive in industrialized countries and its role in drug-drug interactions is often overlooked. CYP1A2… 
1997
1997
Modulation by mexiletine of action potentials, L-type Ca current and delayed rectifier K current recorded from isolated rabbit atrioventricular nodal myocytes
Abstract Using whole-cell patch clamp recordings at 37°C, we have examined the effects of externally applied mexiletine (a class… 
1995
1995
Pharmacokinetics of mexiletine enantiomers in healthy human subjects. A study of the in vivo serum protein binding, salivary excretion and red blood cell distribution of the enantiomers.
1. The disposition kinetics of serum free (unbound) and total mexiletine enantiomers were studied in 12 healthy subjects… 
1994
1994
High-performance liquid chromatographic analysis using a highly sensitive fluorogenic reagent, 2-anthroyl chloride, and stereoselective determination of the enantiomers of mexiletine in human serum.
1989
1989
The pharmacokinetics of the enantiomers of mexiletine in humans.
1. This study examined the pharmacokinetics of the enantiomers of mexiletine in five healthy subjects who were each given a… 
1989
1989
Pharmacokinetics of Mexiletine in the Elderly
The effect of advancing age on the kinetics of the antiarrhythmic agent mexiletine was studied by comparing various kinetic… 
1987
1987
Stereoselective analysis of the enantiomers of mexiletine by high-performance liquid chromatography using fluorescence detection and study of their stereoselective disposition in man.
1982
1982
A modified gas-liquid chromatographic assay to monitor plasma mexiletine in a tinnitus study.
In a clinical study of betahistidine, diazepam and mexiletine for the oral chemotherapy of tinnitus, the hospital Pharmacy was… 
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