Mexiletine

Known as: (+-)-1-(2,6-Dimethylphenoxy)propan-2-amine, Mexiletina, Mexiletinum 
A local anesthetic and antiarrhythmic (Class IB) agent structurally related to lidocaine. Mexiletine exerts its antiarrhythmic effect by inhibiting… (More)
National Institutes of Health

Papers overview

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Highly Cited
2007
Highly Cited
2007
BACKGROUND Mexiletine (Mex) has been proposed as a gene-specific therapy for patients with long-QT syndrome type 3 (LQT3) caused… (More)
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Highly Cited
2002
Highly Cited
2002
UNLABELLED We investigated the analgesic efficacy of mexiletine and gabapentin on acute and chronic pain associated with cancer… (More)
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Review
1999
Review
1999
Tricyclic antidepressants and carbamazepine have become the mainstay in the treatment of neuropathic pain. Within the last decade… (More)
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Highly Cited
1998
Highly Cited
1998
BACKGROUND Painful sensory neuropathy is a common complication of HIV infection. Based on prior uncontrolled observations, we… (More)
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Highly Cited
1998
Highly Cited
1998
BACKGROUND This study examines the cellular basis for the phenotypic appearance of broad-based T waves, increased transmural… (More)
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Highly Cited
1997
Highly Cited
1997
BACKGROUND This study examines the contribution of transmural heterogeneity of transmembrane activity to phenotypic T-wave… (More)
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1996
1996
Severe pain occurs in 5-30% of the spinal cord-injured (SCI) population and is difficult to treat. Subarachnoid lidocaine has… (More)
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Highly Cited
1995
Highly Cited
1995
BACKGROUND The genes for the long QT syndrome (LQTS) linked to chromosomes 3 (LQT3) and 7 (LQT2) were identified as SCN5A, the… (More)
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1992
1992
OBJECTIVE To prove the efficacy of mexiletine in painful diabetic neuropathy. RESEARCH DESIGN AND METHODS Treatment was… (More)
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Highly Cited
1988
Highly Cited
1988
Sixteen of nineteen patients completed a randomised double-blind crossover trial to assess the effect of oral mexiletine (10 mg… (More)
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