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Metolazone

Known as: Metolazonum, 2-Methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone, 6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo- 
A long acting, quinazoline-based sulfonamide thiazide-like, diuretic. Similar to the thiazides, metolazone acts on the distal convoluted tubule (DCT… 
National Institutes of Health

Related topics

Related topics

27 relations

Broader (3)

Antihypertensive AgentsDiureticsQuinazolines
AnuriaComatoseCongestive heart failureDecreased Blood Pressure [PE]

Narrower (3)

DiuloMykroxZaroxolyn

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2015
Review
2015
Early management of patients with acute heart failure: state of the art and future directions. A consensus document from the society for academic emergency medicine/heart failure society of America…
Highly Cited
2008
Highly Cited
2008
Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adduct.
Review
2003
Review
2003
Metolazone and its role in edema management.
Metolazone is commonly administered in conjunction with a loop diuretic to manage volume overload in patients otherwise resistant… 
Highly Cited
1997
Highly Cited
1997
Double‐Blind Comparison of Losartan, Lisinopril, and Metolazone in Elderly Hypertensive Patients with Previous Angiotensin‐Converting Enzyme Inhibitor‐Induced Cough
This study compared the incidence of cough with the angiotensin‐converting enzyme (ACE) inhibitor lisinopril and the diuretic… 
Highly Cited
1996
Highly Cited
1996
Thiazide treatment of rats provokes apoptosis in distal tubule cells.
We studied the effects of inhibition of apical NaCl entry on the structural correlates for electrolyte transport in the distal… 
1992
1992
Diuretic screening in human urine by gas chromatography-mass spectrometry: use of a macroreticular acrylic copolymer for the efficient removal of the coextracted phase-transfer reagent after…
1987
1987
Modification of the peripheral-type benzodiazepine receptor by arachidonate, diethylpyrocarbonate and thiol reagents.
1987
1987
Liquid chromatographic screening of diuretics in urine.
Highly Cited
1974
Highly Cited
1974
Pharmacokinetics of metolazone in normal subjects and in patients with cardiac or renal failure
The pharmacokinetics of metolazane (Zaroxolyn) have been studied in normal adult volunteers after oral or intravenous… 
1972
1972
Effects of metolazone on renal function in normal man.
The renal effects of metolazone, a new sulfonamide diuretic, were investigated in normal volunteers. Metolazone given i.v. to… 
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