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Metolazone

Known as: Metolazonum, 2-Methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone, 6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo- 
A long acting, quinazoline-based sulfonamide thiazide-like, diuretic. Similar to the thiazides, metolazone acts on the distal convoluted tubule (DCT… 
National Institutes of Health

Related topics

Related topics

27 relations

Broader (3)

Antihypertensive AgentsDiureticsQuinazolines
AnuriaComatoseCongestive heart failureDecreased Blood Pressure [PE]

Narrower (3)

DiuloMykroxZaroxolyn

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2013
2013
Comparison of Bumetanide- and Metolazone-Based Diuretic Regimens to Furosemide in Acute Heart Failure
Introduction: Limited data exist comparing the efficacy and safety of bumetanide- or metolazone-based diuretic regimens to… 
2004
2004
FI-chemiluminometric study of thiazides by on-line photochemical reaction.
2000
2000
Effect of Heart Failure Program on Cardiovascular Drug Utilization and Dosage in Patients with Chronic Heart Failure
Background: Utilization and dosage of angiotensin‐converting enzyme (ACE) inhibitors in patients with chronic heart failure (CHF… 
1992
1992
Diuretic screening in human urine by gas chromatography-mass spectrometry: use of a macroreticular acrylic copolymer for the efficient removal of the coextracted phase-transfer reagent after…
Review
1991
Review
1991
Combination antihypertensive therapy with terazosin and other antihypertensive agents: results of clinical trials.
1987
1987
Liquid chromatographic screening of diuretics in urine.
1987
1987
Modification of the peripheral-type benzodiazepine receptor by arachidonate, diethylpyrocarbonate and thiol reagents.
1978
1978
Severe electrolyte disturbances associated with metolazone and furosemide.
In two patients with severe hypertension and moderately severe renal insufficiency, metolazone and furosemide were used in… 
1974
1974
Comparative study of the effects of metolazone and other diuretics on potassium excretion
The acute effects on potassium excretion of the new diuretic agent, metolazone, were compared to those of chlorothiazide… 
1970
1970
Standard oral water load to determine the site of action of diuretics in man With data on metolazone, a new diuretic
Two male volunteers were given metolazone, a new diuretic, intravenously during a stable protracted water diuresis. The drug… 
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