Metolazone

Known as: Metolazonum, 2-Methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone, 6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo- 
A long acting, quinazoline-based sulfonamide thiazide-like, diuretic. Similar to the thiazides, metolazone acts on the distal convoluted tubule (DCT… (More)
National Institutes of Health

Papers overview

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2015
2015
AIMS Sequential nephron blockade with thiazide-like diuretics is a strategy used to overcome diuretic resistance in acute… (More)
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Review
2003
Review
2003
Metolazone is commonly administered in conjunction with a loop diuretic to manage volume overload in patients otherwise resistant… (More)
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Highly Cited
2002
Highly Cited
2002
BACKGROUND In patients with chronic heart failure (CHF), diuretic requirements increase as the disease progresses. Because… (More)
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1997
1997
This study compared the incidence of cough with the angiotensin-converting enzyme (ACE) inhibitor lisinopril and the diuretic… (More)
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1996
1996
The stability of drugs commonly prescribed for use in oral liquid dosage forms but not commercially available as such was studied… (More)
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1990
1990
17 patients with New York Heart Association (NYHA) class IV congestive cardiac failure, refractory to conventional treatment… (More)
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1990
1990
The effect of a number of ions on the binding of the thiazide-type diuretic metolazone (MTZ) to rat renal cortical membranes was… (More)
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1986
1986
Ten patients with severe congestive heart failure (6 women and 4 men, aged 67 +/- 4.35 years) were given diuretic therapy with… (More)
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1981
1981
Features of the brachydactyly in this family were similar to those described by Vidal,4 and the variation in severity among… (More)
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1972
1972
Metolazone is a modified quinazolinesulphonamide and in a dose of between 4 and 7.5 mg is an effective diuretic in man with… (More)
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