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Metolazone

Known as: Metolazonum, 2-Methyl-3-o-tolyl-6-sulfamyl-7-chloro-1,2,3,4-tetrahydro-4-quinazolinone, 6-Quinazolinesulfonamide, 7-chloro-1,2,3,4-tetrahydro-2-methyl-3-(2-methylphenyl)-4-oxo- 
A long acting, quinazoline-based sulfonamide thiazide-like, diuretic. Similar to the thiazides, metolazone acts on the distal convoluted tubule (DCT… Expand
National Institutes of Health

Papers overview

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Review
2015
Review
2015
Heart failure (HF) afflicts nearly 6 million Americans, resulting in one million emergency department (ED) visits and over one… Expand
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Review
2003
Review
2003
  • D. Sica
  • Congestive heart failure
  • 2003
  • Corpus ID: 9221766
Metolazone is commonly administered in conjunction with a loop diuretic to manage volume overload in patients otherwise resistant… Expand
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Highly Cited
2002
Highly Cited
2002
BACKGROUND In patients with chronic heart failure (CHF), diuretic requirements increase as the disease progresses. Because… Expand
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Highly Cited
1997
Highly Cited
1997
This study compared the incidence of cough with the angiotensin‐converting enzyme (ACE) inhibitor lisinopril and the diuretic… Expand
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Highly Cited
1996
Highly Cited
1996
We studied the effects of inhibition of apical NaCl entry on the structural correlates for electrolyte transport in the distal… Expand
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Highly Cited
1994
Highly Cited
1994
OBJECTIVES--(a) To test the hypothesis that a fixed 3 day course of the combination of a thiazide and loop diuretic is as… Expand
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Highly Cited
1990
Highly Cited
1990
17 patients with New York Heart Association (NYHA) class IV congestive cardiac failure, refractory to conventional treatment… Expand
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Highly Cited
1981
Highly Cited
1981
Abstract Seven elderly patients were encountered who had been taking thiazides or thiazide-like diuretics (hydrochlorothiazide… Expand
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Highly Cited
1974
Highly Cited
1974
The pharmacokinetics of metolazane (Zaroxolyn) have been studied in normal adult volunteers after oral or intravenous… Expand
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1972
1972
The renal effects of metolazone, a new sulfonamide diuretic, were investigated in normal volunteers. Metolazone given i.v. to… Expand
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