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Methylpurine DNA Glycosylase

Known as: DNA Glycosylase, Methylpurine, Glycosylase, Methylpurine DNA 
National Institutes of Health

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DNA glycosylase

Papers overview

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2012
2012
N-methylpurine DNA glycosylase inhibits p53-mediated cell cycle arrest and coordinates with p53 to determine sensitivity to alkylating agents
Alkylating agents induce genome-wide base damage, which is repaired mainly by N-methylpurine DNA glycosylase (MPG). An elevated… 
Highly Cited
2011
Highly Cited
2011
N-methylpurine DNA glycosylase and DNA polymerase beta modulate BER inhibitor potentiation of glioma cells to temozolomide.
Temozolomide (TMZ) is the preferred chemotherapeutic agent in the treatment of glioma following surgical resection and/or… 
2011
2011
N-methylpurine DNA glycosylase plays a pivotal role in the threshold response of ethyl methanesulfonate-induced chromosome damage.
Genotoxic tolerance to low-level exposure of monofunctional alkylating agents is compound specific, with the mechanism pertaining… 
2009
2009
DNA damage after phototherapy in wounded fibroblast cells irradiated with 16 J/cm(2).
Highly Cited
2008
Highly Cited
2008
Human Methyl Purine DNA Glycosylase and DNA Polymerase β Expression Collectively Predict Sensitivity to Temozolomide
Overexpression of N-methylpurine DNA glycosylase (MPG) has been suggested as a possible gene therapy approach to sensitize tumor… 
Highly Cited
2007
Highly Cited
2007
Manipulation of Base Excision Repair to Sensitize Ovarian Cancer Cells to Alkylating Agent Temozolomide
Purpose: To improve the treatment of women with ovarian cancer, we are investigating the modulation of a prominent DNA-damaging… 
2006
2006
N-METHYLPURINE DNA GLYCOSYLASE AND 8-OXOGUANINE DNA GLYCOSYLASE METABOLIZE THE ANTIVIRAL NUCLEOSIDE 2-BROMO-5,6-DICHLORO-1-(β-D-RIBOFURANOSYL)BENZIMIDAZOLE
The rapid in vivo degradation of the potent human cytomegalovirus inhibitor 2-bromo-5,6-dichloro-1-(β-d-ribofuranosyl… 
2005
2005
Amino Acid Ester Prodrugs of 2-Bromo-5,6-dichloro-1-(β-d-ribofuranosyl)benzimidazole Enhance Metabolic Stability in Vitro and in Vivo
2-Bromo-5,6-dichloro-1-(β-d-ribofuranosyl)benzimidazole (BDCRB) is a potent and selective inhibitor of human cytomegalovirus… 
Highly Cited
2003
Highly Cited
2003
Imbalancing the DNA base excision repair pathway in the mitochondria; targeting and overexpressing N-methylpurine DNA glycosylase in mitochondria leads to enhanced cell killing.
The DNA base excision repair (BER) pathway is responsible for the repair of alkylation and oxidative DNA damage. The short-patch… 
2002
2002
Methylpurine DNA glycosylase of the hyperthermophilic archaeon Archaeoglobus fulgidus.
Base excision repair of DNA alkylation damage is initiated by a methylpurine DNA glycosylase (MPG) function. Such enzymes have… 
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