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DNA glycosylase

Known as: Glycosylase, DNA, DNA N glycosidase, DNA N-glycosidase 
A family of DNA repair enzymes that recognize damaged nucleotide bases and remove them by hydrolyzing the N-glycosidic bond that attaches them to the… 
National Institutes of Health

Related topics

Related topics

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Narrower (16)

3-methyladenine-DNA glycosylase5-bromouracil DNA glycosylaseAmun protein, DrosophilaDML2 protein, Arabidopsis
DNA N-glycosylase activityIn BloodProcess of secretionantagonists & inhibitors

Papers overview

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Highly Cited
2004
Highly Cited
2004
DNA damage and repair in type 2 diabetes mellitus.
Highly Cited
2003
Highly Cited
2003
Mammalian 5-formyluracil-DNA glycosylase. 2. Role of SMUG1 uracil-DNA glycosylase in repair of 5-formyluracil and other oxidized and deaminated base lesions.
In the accompanying paper [Matsubara, M., et al. (2003) Biochemistry 42, 4993-5002], we have partially purified and characterized… 
Highly Cited
2002
Highly Cited
2002
Altering the pathway of immunoglobulin hypermutation by inhibiting uracil-DNA glycosylase
A functional immune system depends on the production of a wide range of immunoglobulin molecules. Immunoglobulin variable region… 
Highly Cited
2001
Highly Cited
2001
Repair of 8-oxodeoxyguanosine lesions in mitochondrial dna depends on the oxoguanine dna glycosylase (OGG1) gene and 8-oxoguanine accumulates in the mitochondrial dna of OGG1-defective mice.
Mitochondria are not only the major site for generation of reactive oxygen species, but also one of the main targets of oxidative… 
Review
2000
Review
2000
Base excision repair of DNA in mammalian cells
Highly Cited
2000
Highly Cited
2000
Uracil-DNA glycosylase-DNA substrate and product structures: conformational strain promotes catalytic efficiency by coupled stereoelectronic effects.
Enzymatic transformations of macromolecular substrates such as DNA repair enzyme/DNA transformations are commonly interpreted… 
Highly Cited
1998
Highly Cited
1998
Crystal Structure of a Human Alkylbase-DNA Repair Enzyme Complexed to DNA Mechanisms for Nucleotide Flipping and Base Excision
Highly Cited
1995
Highly Cited
1995
Properties of a recombinant human uracil-DNA glycosylase from the UNG gene and evidence that UNG encodes the major uracil-DNA glycosylase.
We have expressed a human recombinant uracil-DNA glycosylase (UNG delta 84) closely resembling the mature form of the human… 
Highly Cited
1991
Highly Cited
1991
A human nuclear uracil DNA glycosylase is the 37-kDa subunit of glyceraldehyde-3-phosphate dehydrogenase.
We have isolated and characterized a plasmid (pChug 20.1) that contains the cDNA of a nuclear uracil DNA glycosylase (UDG) gene… 
Highly Cited
1987
Highly Cited
1987
Formamidopyrimidine‐DNA glycosylase of Escherichia coli: cloning and sequencing of the fpg structural gene and overproduction of the protein.
An Escherichia coli genomic library composed of large DNA fragments (10‐15 kb) was constructed using the plasmid pBR322 as vector… 
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