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DNA glycosylase

Known as: Glycosylase, DNA, DNA N glycosidase, DNA N-glycosidase 
A family of DNA repair enzymes that recognize damaged nucleotide bases and remove them by hydrolyzing the N-glycosidic bond that attaches them to the… 
National Institutes of Health

Related topics

Related topics

24 relations

Narrower (16)

3-methyladenine-DNA glycosylase5-bromouracil DNA glycosylaseAmun protein, DrosophilaDML2 protein, Arabidopsis
DNA N-glycosylase activityIn BloodProcess of secretionantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2010
2010
Inactivation by oxidation and recruitment into stress granules of hOGG1 but not APE1 in human cells exposed to sub-lethal concentrations of cadmium.
Highly Cited
2001
Highly Cited
2001
5-Methylcytosine DNA glycosylase participates in the genome-wide loss of DNA methylation occurring during mouse myoblast differentiation.
Changes in gene expression during mouse myoblast differentiation were monitored by DNA microarray hybridisation. Four days after… 
Highly Cited
1999
Highly Cited
1999
Expression of DNA repair proteins hMSH2, hMSH6, hMLH1, O6‐methylguanine‐DNA methyltransferase and N‐methylpurine‐DNA glycosylase in melanoma cells with acquired drug resistance
Malignant melanoma is well known for its primary unresponsiveness to chemotherapy. The mechanisms conferring this intrinsic… 
Review
1998
Review
1998
Antimutagenic role of base-excision repair enzymes upon free radical-induced DNA damage.
Highly Cited
1998
Highly Cited
1998
Mammalian 3-methyladenine DNA glycosylase protects against the toxicity and clastogenicity of certain chemotherapeutic DNA cross-linking agents.
DNA repair status is recognized as an important determinant of the clinical efficacy of cancer chemotherapy. To assess the role… 
Highly Cited
1997
Highly Cited
1997
Demethylation of DNA by purified chick embryo 5-methylcytosine-DNA glycosylase requires both protein and RNA.
We have previously purified and characterized a 5-methylcytosine (5-MeC)-DNA glycosylase from 12 day old chick embryos [Jost,J.P… 
Highly Cited
1994
Highly Cited
1994
1,N6-ethenoadenine is preferred over 3-methyladenine as substrate by a cloned human N-methylpurine-DNA glycosylase (3-methyladenine-DNA glycosylase).
A lethal DNA adduct induced by methylating agents, 3-methyladenine (m3A), is removed by both the constitutive (Tag) and inducible… 
Highly Cited
1986
Highly Cited
1986
Regulatory mechanisms for induction of synthesis of repair enzymes in response to alkylating agents: ada protein acts as a transcriptional regulator.
Expression of the ada and alkA genes, both of which are involved in the adaptive response of Escherichia coli to alkylating… 
Highly Cited
1981
Highly Cited
1981
Induction of the DNA repair enzymes uracil DNA glycosylase and 3-methyladenine DNA glycosylase in regenerating rat liver.
The capacity of eukaryotic cells to modulate the activities of DNA repair enzymes during cell proliferation was examined. Using… 
Highly Cited
1980
Highly Cited
1980
den V gene of bacteriophage T4 determines a DNA glycosylase specific for pyrimidine dimers in DNA
Endonuclease V of bacteriophage T4 has been described as an enzyme, coded for by the denV gene, that incises UV-irradiated DNA… 
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