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3-methyladenine-DNA glycosylase

Known as: alkyladenine DNA glycosylase, 3-MeAde-DNA glycosylase, N-Methylpurine-DNA Glycosylase 
DNA-3-methyladenine glycosylase (298 aa, ~33 kDa) is encoded by the human MPG gene. This protein plays a role in the excision of alkylated bases from… 
National Institutes of Health

Related topics

Related topics

10 relations
Cell NucleusDNA RepairDNA repair proteinDNA-3-methyladenine glycosidase II

Broader (1)

DNA glycosylase

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Repair of Alkylation Damage in Eukaryotic Chromatin Depends on Searching Ability of Alkyladenine DNA Glycosylase.
Human alkyladenine DNA glycosylase (AAG) initiates the base excision repair pathway by excising alkylated and deaminated purine… 
2011
2011
Substitution of active site tyrosines with tryptophan alters the free energy for nucleotide flipping by human alkyladenine DNA glycosylase.
Human alkyladenine DNA glycosylase (AAG) locates and excises a wide variety of structurally diverse alkylated and oxidized purine… 
2004
2004
Cloning of Escherichia coli genes encoding 3-methyladenine DNA glycosylases I and II
SummaryWe have constructed two recombinant plasmids which harbour functions involved in DNA repair of alkylation damage in… 
2002
2002
Effects of Hydrogen Bonding within a Damaged Base Pair on the Activity of Wild Type and DNA-intercalating Mutants of Human Alkyladenine DNA Glycosylase*
Human alkyladenine DNA glycosylase “flips” damaged DNA bases into its active site where excision occurs. Tyrosine 162 is inserted… 
2002
2002
Alkylation resistance of E. coli cells expressing different isoforms of human alkyladenine DNA glycosylase (hAAG).
2000
2000
Cisplatin adducts inhibit 1,N(6)-ethenoadenine repair by interacting with the human 3-methyladenine DNA glycosylase.
The human 3-methyladenine DNA glycosylase (AAG) is a repair enzyme that removes a number of damaged bases from DNA, including… 
Highly Cited
1998
Highly Cited
1998
Specific interaction of wild-type and truncated mouse N-methylpurine-DNA glycosylase with ethenoadenine-containing DNA.
N-Methylpurine-DNA glycosylase (MPG), a ubiquitous DNA repair enzyme, is responsible for the removal of a wide variety of… 
1995
1995
Structural organization of the mouse DNA repair gene, N-methylpurine-DNA glycosylase.
N-Methylpurine-DNA glycosylase (MPG), a ubiquitous DNA repair enzyme, removes N-alkylpurines and other purine lesions induced in… 
Highly Cited
1994
Highly Cited
1994
1,N6-ethenoadenine is preferred over 3-methyladenine as substrate by a cloned human N-methylpurine-DNA glycosylase (3-methyladenine-DNA glycosylase).
A lethal DNA adduct induced by methylating agents, 3-methyladenine (m3A), is removed by both the constitutive (Tag) and inducible… 
1982
1982
Partial purification and characterization of 3-methyladenine-DNA glycosylase from human placenta.
A DNA glycosylase was isolated and purified over 1000-fold from human placentas by means of diethylamino-ethylcellulose and… 
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