Comparison of Human Duodenum and Caco-2 Gene Expression Profiles for 12,000 Gene Sequences Tags and Correlation with Permeability of 26 Drugs
- Duxin Sun, H. Lennernas, G. Amidon
- BiologyPharmaceutical Research
- 1 October 2002
Gene expression profiling is a valuable new tool for investigating in vitro and in vivo permeability correlation and was consistent with observed differences in carrier mediated drug permeabilities.
Why is it Challenging to Predict Intestinal Drug Absorption and Oral Bioavailability in Human Using Rat Model
- Xianhua Cao, S. Gibbs, Duxin Sun
- BiologyPharmaceutical Research
- 14 July 2006
The data indicate that rat and human show similar drug intestinal absorption profiles and similar transporter expression patterns in the small intestine, while the two species exhibit distinct expression levels and patterns for metabolizing enzymes in the intestine.
The role of TRPV6 in breast carcinogenesis
- K. Bolanz, M. Hediger, C. Landowski
- Biology, MedicineMolecular Cancer Therapeutics
- 1 February 2008
The in vitro model showed that TRPV6 can be regulated by estrogen, progesterone, tamoxifen, and 1,25-vitamin D and has a large influence on breast cancer cell proliferation.
Mechanisms and regulation of epithelial Ca2+ absorption in health and disease.
- Yoshiro Suzuki, C. Landowski, M. Hediger
- BiologyAnnual Review of Physiology
- 13 February 2008
The results indicate that the genes for TRPV5 andTRPV6 are differentially regulated in human diseases associated with disturbed Ca2+ balance such as hypercalciuria, osteoporosis, and vitamin D-resistant rickets.
Calcium Channel TRPV6 Is Involved in Murine Maternal–Fetal Calcium Transport
- Yoshiro Suzuki, C. Kovacs, H. Takanaga, Ji-Bin Peng, C. Landowski, M. Hediger
- BiologyJournal of Bone and Mineral Research
- 1 August 2008
The results provide the first in vivo evidence that TRPV6 is involved in maternal–fetal Ca2+ transport, and it is proposed that TRpV6 functions as a Ca2- entry pathway, which is critical for fetal Ca2+, homeostasis.
Comparative gene expression profiles of intestinal transporters in mice, rats and humans.
- Hye-Ryoung Kim, Sung-won Park, Ho-Chul Shin
- BiologyPharmacological Research
- 1 September 2007
Characterization of a stem cell population in lung cancer A549 cells.
- J. Sung, Hee-Jung Cho, Ho-Chul Shin
- Biology, MedicineBiochemical and Biophysical Research…
- 20 June 2008
Amino acid ester prodrugs of the anticancer agent gemcitabine: synthesis, bioconversion, metabolic bioevasion, and hPEPT1-mediated transport.
- Xueqin Song, P. Lorenzi, C. Landowski, B. Vig, J. Hilfinger, G. Amidon
- Biology, ChemistryMolecular Pharmaceutics
- 16 March 2005
The combined results suggest that the disposition of gemcitabine following oral administration would be controlled by the rate of bioconversion following transport across the intestinal epithelial membrane and that it may be possible to modulate these characteristics by the choice of the amino acid promoiety.
Enabling Low Cost Biopharmaceuticals: A Systematic Approach to Delete Proteases from a Well-Known Protein Production Host Trichoderma reesei
- C. Landowski, Anne Huuskonen, M. Saloheimo
- BiologyPLoS ONE
- 26 August 2015
The seven most problematic proteases were sequentially removed from a strain to develop it for producing therapeutic proteins and led to faster strain growth and higher levels of total protein in the culture supernatant.
Gene Expression in the Human Intestine and Correlation with Oral Valacyclovir Pharmacokinetic Parameters
- C. Landowski, Duxin Sun, G. Amidon
- Biology, ChemistryJournal of Pharmacology and Experimental…
- 1 August 2003
Correlations of pharmacokinetic parameters following oral valacyclovir or acyclovIR administration with expression levels of intestinal genes in humans are described and it is suggested that the role of HPT1 in transport of peptides and peptidomimetics drugs needs to be examined in more detail.