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Methyldopa

Known as: (S)-(-)-alpha-Methyldopa, L-Tyrosine, 3-hydroxy-alpha-methyl-, Methyldopa [Chemical/Ingredient] 
A phenylalanine derivative and an aromatic amino acid decarboxylase inhibitor with antihypertensive activity. Methyldopa is a prodrug and is… 
National Institutes of Health

Related topics

Related topics

33 relations

Broader (4)

Adrenergic alpha-2 Receptor AgonistsAntihypertensive AgentsDopaSympatholytics
Adrenergic alpha2-Agonists [MoA]CatecholaminesDecreased Blood Pressure [PE]Dopamine

Narrower (9)

AldometCarbidopaDopametDopegyt

Papers overview

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Highly Cited
1982
Highly Cited
1982
Effect of methyldopa, clonidine, and hydralazine on cardiac mass and haemodynamics in Wistar Kyoto and spontaneously hypertensive rats.
Prolonged treatment of spontaneously hypertensive (SHR) rats with either methyldopa or clonidine significantly and similarly… 
1979
1979
Studies on the mechanism of lanosterol 14 alpha-demethylation. A requirement for two distinct types of mixed-function-oxidase systems.
Carbon monoxide inhibited the removal of C-32 of dihydrolanosterol (I), but not of its metabolites 5 alpha-lanost-8-ene-3 beta,32… 
Highly Cited
1977
Highly Cited
1977
Binding of 4-methylumbelliferyl alpha-D-mannopyranoside to tetrameric and unmodified or derivatized dimeric concanavalin A: equilibrium studies.
The binding of 4-methylumbelliferyl alpha-D-mannopyranoside (MUM) and concanavalin A, composed of intact polypeptide chains, was… 
Highly Cited
1977
Highly Cited
1977
Comparative serological and cutaneous reactivity of candidal cytoplasmic proteins and mannan separated by affinity for concanavalin A
Yeast-form Candida albicans cells were disrupted for 1.5 min in a Braun homogenizer and centrifuged at 100,000 X g. The… 
1977
1977
Thyrotropin-releasing hormone content of rat brain and hypothalamus: results of endocrine and pharmacologic treatments.
Studies of hypothalamic and regional brain TRH content in the rat after administration of various hormonal and pharmacologic… 
Highly Cited
1976
Highly Cited
1976
Influence of dopaminergic agonists and antagonists on serum prolactin concentrations in the rat.
Inhibitors of dopaminergic neurotransmission, such as reserpine (RES), given alone or combined with alpha-methyl-p-tyrosine… 
1976
1976
Characteristics of the association between prothrombin fragment 2 and alpha-thrombin.
The esterolytic activity of bovine alpha-thrombin on the synthetic substrate N-alpha-p-tosyl-L-arninine methyl ester (TosArgOMe… 
Highly Cited
1975
Highly Cited
1975
Quantitative microfluorimetry of formaldehyde induced fluorescence of dopamine in the caudate nucleus.
Quantitative microfluorimetric studies were carried out on the formaldehyde induced fluorescence of dopamine in nerve terminals… 
1973
1973
Binding of 13 C-enriched -methyl-D-glucopyranoside to concanavalin A as studied by carbon magnetic resonance.
Binding of alpha-methyl-D-glucopyranoside, uniformly enriched with 14% (13)C, to zinc and manganese derivatives of concanavalin A… 
Highly Cited
1972
Highly Cited
1972
Inhibition of cellular transport processes by 5-thio-D-glucopyranose.
5-Thio-d-glucopyranose, the nearest analogue of normal d-glucose, which is proving a useful tool in examinations of d-glucose…