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Methoxyflurane

Known as: Methyl 1,1-difluoro-2,2-dichloroethyl ether, 2,2-Dichloro-1,1-difluoro-1-methoxyethane, Methofluranum 
An inhalation anesthetic. Currently, methoxyflurane is rarely used for surgical, obstetric, or dental anesthesia. If so employed, it should be… Expand
National Institutes of Health

Papers overview

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Highly Cited
2003
Highly Cited
2003
P-Glycoprotein (Pgp) in the blood-brain barrier limits the uptake of substrate drugs into the brain. We have determined the… Expand
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Highly Cited
2000
Highly Cited
2000
Interleukin 8 (IL-8) is mitogenic and chemotactic for endothelial cells. Within a neoplasm, IL-8 is secreted by inflammatory and… Expand
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Highly Cited
2000
Highly Cited
2000
Malignant pleural effusion (PE) is associated with advanced human lung cancer. We found recently, using a nude mouse model, that… Expand
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Highly Cited
1997
Highly Cited
1997
The level of expression and interindividual variation in human hepatic microsomal cytochrome P450 (CYP) 2B6 was characterized… Expand
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Highly Cited
1997
Highly Cited
1997
The effects of riluzole, a neuroprotective drug, on tetrodotoxin-sensitive (TTX-S) and tetrodotoxin-resistant (TTX-R) sodium… Expand
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Highly Cited
1994
Highly Cited
1994
BackgroundMethoxyflurane nephrotoxicity is mediated by cytochrome P450-catalyzed metabolism to toxic metabolites. It is… Expand
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Highly Cited
1993
Highly Cited
1993
BackgroundRenal and hepatic toxicity of the fluorinated ether volatile anesthetics is caused by biotransformation to toxic… Expand
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Highly Cited
1993
Highly Cited
1993
BACKGROUND--Increased production of transforming growth factor beta (TGF-beta) seems to have an important role in the… Expand
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Highly Cited
1984
Highly Cited
1984
Most proteins are insensitive to the presence of anaesthetics at concentrations which induce general anaesthesia, while some are… Expand
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Highly Cited
1966
Highly Cited
1966
Among 94 cases in which methoxyflurane was used, 16 developed a toxic nephropathy characterized by diuresis. A seventeenth case… Expand
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