Mephobarbital

Known as: Metilfenobarbitale, Metilfenobarbital, 5-Ethyl-1-methyl-5-phenylbarbituric acid 
A barbiturate that is metabolized to PHENOBARBITAL. It has been used for similar purposes, especially in EPILEPSY, but there is no evidence… (More)
National Institutes of Health

Related topics

Related topics

24 relations
Airway ObstructionChildhood Absence EpilepsyDisorders of Porphyrin MetabolismDrug Allergy
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Broader (4)

AnticonvulsantsBarbitalGABA ModulatorsHypnotics and Sedatives

Narrower (2)

MebaralProminal

Papers overview

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2004
2004
A novel single nucleotide polymorphism (SNP) of the CYP2C19 gene in a Japanese subject with lowered capacity of mephobarbital 4'-hydroxylation.
We sequenced all nine exons and exon-intron junctions of the cytochrome P450 2C19 (CYP2C19) gene from a Japanese subject with a… (More)
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Highly Cited
2001
Highly Cited
2001
Transport of Lipophilic Drug Molecules in a New Mucus-Secreting Cell Culture Model Based on HT29-MTX Cells
Purpose. A new mucus-secreting in vitro drug absorption model based on monolayers of goblet-cell like sub-clones of the human… (More)
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Highly Cited
2000
Highly Cited
2000
Teratogenic effects of antiepileptic drugs: use of an International Database on Malformations and Drug Exposure (MADRE).
PURPOSE The study goal was to assess teratogenic effects of antiepileptic drugs (AEDs) through the use of a surveillance system… (More)
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2000
2000
The role of voltage-gated chloride channels in type II pyrethroid insecticide poisoning.
Pyrethroids act on mammalian sodium channels, but we have previously shown that low concentrations of the type II pyrethroid… (More)
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1995
1995
The role of S-mephenytoin hydroxylase (CYP2C19) in the metabolism of the antimalarial biguanides.
The effects of the CYP2C19 substrates, mephenytoin, methsuximide and mephobarbitone on the metabolism of proguanil and… (More)
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1991
1991
Plasma antiepileptic drug concentrations during pregnancy.
Steady-state plasma antiepileptic drug (AED) concentrations were measured at intervals throughout pregnancy and during the… (More)
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1990
1990
The influence of age and gender on the stereoselective metabolism and pharmacokinetics of mephobarbital in humans.
In this clinical investigation, four groups of subjects (eight young women and eight young men [age range, 18 to 25 years], and… (More)
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1986
1986
A randomized, double-blind, crossover study of phenobarbital and mephobarbital.
Some pediatric neurologists maintain that mephobarbital (Mebaral) causes fewer behavioral side effects than phenobarbital… (More)
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1986
1986
Polymorphic metabolism of mephenytoin in man: pharmacokinetic interaction with a co-regulated substrate, mephobarbital.
The simultaneous dosing of two drugs with co-regulated genetic polymorphisms determined by a single cytochrome P-450 isozyme… (More)
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1985
1985
Stereoselective mephobarbital hydroxylation cosegregates with mephenytoin hydroxylation.
The 8-hour urinary recovery of 4-hydroxy-mephobarbital has been measured after oral administration of racemic mephobarbital (90… (More)
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