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The pharmacokinetics of midazolam in man
SummaryMidazolam, a new water-soluble benzodiazepine, was administered as: i) 5 mg intravenously, ii) a 10-mg oral solution and iii) a 10-mg oral tablet, to six volunteers whose informed consent had…
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Critical relationship between sodium valproate dose and human teratogenicity: results of the Australian register of anti-epileptic drugs in pregnancy
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The Australian Register of Antiepileptic Drugs in Pregnancy: The first 1002 pregnancies
TLDR
Prospective studies are needed to assess the maternal and fetal hazards of antiepileptic drug (AED) therapy in pregnancy and the potential risks and benefits of AEDs in pregnancy.
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Convulsive ergotism: epidemics of the serotonin syndrome?
  • M. Eadie
  • Medicine
    The Lancet Neurology
  • 1 July 2003
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Foetal malformations and seizure control: 52 months data of the Australian Pregnancy Registry
TLDR
Data indicate an increased risk of FM in women taking VPA in doses >1100 mg/day compared with other AEDs, and it is noted that more patients on LTG than on VPA required dose adjustments to control seizures.
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Therapeutic drug monitoring--antiepileptic drugs.
  • M. Eadie
  • Medicine, Biology
    British journal of clinical pharmacology
  • 1 September 2001
TLDR
A brief critical review of the basis and contemporary practice of monitoring the concentrations of antiepileptic drugs in biological fluids is provided, based on literature data and observations from clinical practice.
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A Disease Once Sacred: A History of the Medical Understanding of Epilepsy
pH-dependent rearrangement of the biosynthetic ester glucuronide of valproic acid to beta-glucuronidase-resistant forms.
TLDR
It was shown that sample handling and storage conditions of ester glucuronides prior to analysis are of prime importance, since hydrolysis with beta-glucuronidase is frequently used for identification and quantification of glucuronide.
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THE PATHOLOGY OF CERTAIN MEDULLARY NUCLEI IN PARKINSONISM.
  • M. Eadie
  • Medicine
    Brain : a journal of neurology
  • 1 December 1963
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Is lamotrigine a significant human teratogen? Observations from the Australian Pregnancy Register
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