Melphalan

Known as: 4-[bis(2-chloroethyl)amino]-L-phenylalanine, 3-P-(Di(2-chloroethyl)amino)-phenyl-L-alanine, 4-(Bis(2-chloroethyl)amino)phenylalanine 
A phenylalanine derivative of nitrogen mustard with antineoplastic activity. Melphalan alkylates DNA at the N7 position of guanine and induces DNA… (More)

Topic mentions per year

Topic mentions per year

1947-2018
020040019472017

Papers overview

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Highly Cited
2009
Highly Cited
2009
PURPOSE Until recently, melphalan and prednisone were the standards of care in elderly patients with multiple myeloma. The… (More)
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Highly Cited
2008
Highly Cited
2008
BACKGROUND The standard treatment for patients with multiple myeloma who are not candidates for high-dose therapy is melphalan… (More)
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Highly Cited
2008
Highly Cited
2008
The initial analysis of the oral combination melphalan, prednisone, and thalidomide (MPT) in newly diagnosed patients with… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND In multiple myeloma, combination chemotherapy with melphalan plus prednisone is still regarded as the standard of care… (More)
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Highly Cited
2007
Highly Cited
2007
BACKGROUND High-dose chemotherapy followed by autologous hematopoietic stem-cell transplantation has been reported to provide… (More)
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Since 1960, oral melphalan and prednisone (MP) has been regarded as the standard of care in elderly multiple myeloma… (More)
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Highly Cited
2006
Highly Cited
2006
Standard first-line treatment for elderly multiple myeloma (MM) patients ineligible for stem cell transplantation is melphalan… (More)
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Highly Cited
2004
Highly Cited
2004
BACKGROUND AL amyloidosis is a fatal disease resulting from tissue deposition of amyloid fibrils derived from monoclonal… (More)
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Highly Cited
2001
Highly Cited
2001
A reduced-intensity preparative regimen consisting of melphalan and a purine analog was evaluated for allogeneic transplantation… (More)
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Highly Cited
1997
Highly Cited
1997
BACKGROUND Primary systemic amyloidosis is an uncommon disease characterized by the accumulation in vital organs of a fibrillar… (More)
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