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Melphalan

Known as: 4-[bis(2-chloroethyl)amino]-L-phenylalanine, 3-P-(Di(2-chloroethyl)amino)-phenyl-L-alanine, 4-(Bis(2-chloroethyl)amino)phenylalanine 
A phenylalanine derivative of nitrogen mustard with antineoplastic activity. Melphalan alkylates DNA at the N7 position of guanine and induces DNA… 
National Institutes of Health

Related topics

Related topics

45 relations
ACP protocolCisplatin/Doxorubicin/Melphalan/Teniposide regimenDoxorubicin/Melphalan/Teniposide regimen (MAV)In Blood

Narrower (14)

BEM protocolCB-3025K-18 conjugateMDT protocol

Broader (2)

MechlorethamineNitrogen Mustard Compounds

Papers overview

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Highly Cited
2009
Highly Cited
2009
Distribution of mitomycin C induced breaks on human chromosomes.
Mitomycin C induced chromosome aberrations were analysed in cultured human lymphocytes by the quinacrine mustard chromosome… 
Highly Cited
1987
Highly Cited
1987
A single dose of endotoxin activates neutrophils without activating complement.
Both complement (C) and neutrophils (PMN) are activated in critically ill patients. To evaluate the role of endotoxin in this… 
Highly Cited
1986
Highly Cited
1986
Chemotactic peptides modulate adherence of human polymorphonuclear leukocytes to monolayers of cultured endothelial cells.
We have used a new centrifugation assay to examine the effects of highly purified human C5a and C5a des Arg, as well as effects… 
Highly Cited
1983
Highly Cited
1983
Analysis of the bimodal chemiluminescence pattern stimulated in human neutrophils by chemotactic factors
Chemotactic factors, which are important in attracting neutrophils to inflammatory sites, have also been shown to stimulate… 
Highly Cited
1979
Highly Cited
1979
Superoxide production induced in rabbit polymorphonuclear leukocytes by synthetic chemotactic peptides and A23187.
SYNTHETIC FORMYL METHIONYL CHEMOTACTIC PEPTIDES INDUCE THE VARIOUS MANIFESTATIONS OFTHE RESPIRATORY BURST: increased 0(2… 
Highly Cited
1971
Highly Cited
1971
The elastase-like enzymes from Streptomyces griseus (pronase). Isolation and partial characterization.
1 Three elastase-like enzymes, designated Enzyme I, II and III, were purified from a commercial preparation of Streptomyces… 
Highly Cited
1969
Highly Cited
1969
Structural studies on transfer ribonucleic acid. I. Labeling of exposed guanine sites in yeast phenylalanine transfer ribonucleic acid with kethoxal.
Highly Cited
1960
Highly Cited
1960
Serotonin Synthesis in Carcinoid Patients
RECENT investigations in our laboratories have shown that α-methyl-3,4-dihydroxy-DL-phenylalanine (α-methyl-dopa) is an effective… 
Highly Cited
1947
Highly Cited
1947
DISEASE
Background: Little is known about patients who frequently visit the emergency department (ED) for acute exacerbation of chronic… 
Highly Cited
1947
Highly Cited
1947
Nitrogen mustard therapy in cutaneous blastomatous disease.
The paucity of reports in the literature on the use of nitrogen mustard therapy in cutaneous blastomatous disease leads us to…