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Melphalan

Known as: 4-[bis(2-chloroethyl)amino]-L-phenylalanine, 3-P-(Di(2-chloroethyl)amino)-phenyl-L-alanine, 4-(Bis(2-chloroethyl)amino)phenylalanine 
A phenylalanine derivative of nitrogen mustard with antineoplastic activity. Melphalan alkylates DNA at the N7 position of guanine and induces DNA… 
National Institutes of Health

Related topics

Related topics

45 relations
ACP protocolCisplatin/Doxorubicin/Melphalan/Teniposide regimenDoxorubicin/Melphalan/Teniposide regimen (MAV)In Blood

Narrower (14)

BEM protocolCB-3025K-18 conjugateMDT protocol

Broader (2)

MechlorethamineNitrogen Mustard Compounds

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
1989
1989
Altered free cytosolic calcium changes and neutrophil chemotaxis in patients with juvenile periodontitis.
Nearly 70-75% of patients with localized juvenile periodontitis (JP) have abnormal polymorphonuclear leukocytic (PMN) chemotaxis… 
Highly Cited
1987
Highly Cited
1987
A single dose of endotoxin activates neutrophils without activating complement.
Both complement (C) and neutrophils (PMN) are activated in critically ill patients. To evaluate the role of endotoxin in this… 
Highly Cited
1984
Highly Cited
1984
Human leukocyte interferon and intermittent high-dose melphalan-prednisone administration in the treatment of multiple myeloma: a randomized clinical trial from the Myeloma Group of Central Sweden.
In a randomized clinical trial intermittent high-dose melphalan/prednisone (MP) treatment has been compared with human leukocyte… 
1982
1982
Effect of in vitro preincubation of polymorphonuclear leukocytes on formylmethionyl-leucyl-phenylalanine-induced chemiluminescence
When polymorphonuclear leukocytes (PMNL) and soluble or particulate matter interact, the cells produce chemiluminescence. The… 
Highly Cited
1969
Highly Cited
1969
An application of transient nuclear magnetic resonance methods to the measurement of biological exchange rates. The interaction of trifluoroacetyl-D-phenylalanine with the chymotrypsins.
Highly Cited
1968
Highly Cited
1968
Studies on polynucleotides. LXXXII. Yeast phenylalanine transfer ribonucleic acid: partial digestion with ribonuclease T-1 and derivation of the total primary structure.
Abstract Large oligonucleotide fragments obtained by partial digestion of yeast phenylalanine transfer ribonucleic acid with… 
Highly Cited
1967
Highly Cited
1967
The interaction of actinomycin with DNA: requirement for the 2-amino group of purines.
The formation of complexes between actinomycin (AM) (Fig. 1) and DNA is known to depend on specific structures in both the… 
Highly Cited
1963
Highly Cited
1963
The sensitivity of cultured mammalian cells in different stages of the division cycle to nitrogen and sulfur mustards.
Summary Strain L mouse fibroblasts growing in vitro were exposed to varying concentrations of nitrogen and sulfur mustards, and… 
1960
1960
Studies on the precursors of the methyl groups of choline in rat liver.
Since the original demonstrations by du Vigneaud et al. (l-4) that the methyl group of labeled methionine can be transferred… 
Highly Cited
1947
Highly Cited
1947
DISEASE
Background: Little is known about patients who frequently visit the emergency department (ED) for acute exacerbation of chronic…