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Melphalan

Known as: 4-[bis(2-chloroethyl)amino]-L-phenylalanine, 3-P-(Di(2-chloroethyl)amino)-phenyl-L-alanine, 4-(Bis(2-chloroethyl)amino)phenylalanine 
A phenylalanine derivative of nitrogen mustard with antineoplastic activity. Melphalan alkylates DNA at the N7 position of guanine and induces DNA… Expand
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
BACKGROUND The standard treatment for patients with multiple myeloma who are not candidates for high-dose therapy is melphalan… Expand
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Highly Cited
2007
Highly Cited
2007
BACKGROUND In multiple myeloma, combination chemotherapy with melphalan plus prednisone is still regarded as the standard of care… Expand
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Highly Cited
2006
Highly Cited
2006
BACKGROUND Since 1960, oral melphalan and prednisone (MP) has been regarded as the standard of care in elderly multiple myeloma… Expand
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Review
2004
Review
2004
Context AL amyloidosis responds poorly to oral chemotherapy and rarely leads to elimination of plasma cell dyscrasia. Amyloid… Expand
Highly Cited
2001
Highly Cited
2001
A reduced-intensity preparative regimen consisting of melphalan and a purine analog was evaluated for allogeneic transplantation… Expand
Highly Cited
1997
Highly Cited
1997
BACKGROUND Primary systemic amyloidosis is an uncommon disease characterized by the accumulation in vital organs of a fibrillar… Expand
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Highly Cited
1992
Highly Cited
1992
PURPOSE To determine the toxicity and the therapeutic efficacy of the combination of the recombinant tumor necrosis factor alpha… Expand
Highly Cited
1983
Highly Cited
1983
1 previously untreated patient with plasma-cell leukaemia and 8 patients with myeloma (4 previously untreated) were treated with… Expand
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Highly Cited
1969
Highly Cited
1969
Of 183 patients with multiple myeloma treated with melphalan, 43% demonstrated an objective response. Of the evaluable cases, 70… Expand
Highly Cited
1947
Highly Cited
1947
  • 1947
  • Corpus ID: 222064452