Skip to search formSkip to main contentSkip to account menu

Melanocortin 4 Receptor

Known as: Receptor 4, Melanocortin, Receptor, Melanocortin 4, Receptor, MC4 
A melanocortin receptor subtype found primarily in BRAIN. It shows specificity for ALPHA-MSH; BETA-MSH and ADRENOCORTICOTROPIC HORMONE.
National Institutes of Health

Related topics

Related topics

6 relations
In BloodMC4R geneagonistsantagonists & inhibitors

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2016
Highly Cited
2016
Proopiomelanocortin Deficiency Treated with a Melanocortin-4 Receptor Agonist.
Patients with rare defects in the gene encoding proopiomelanocortin (POMC) have extreme early-onset obesity, hyperphagia… 
Highly Cited
2013
Highly Cited
2013
Developmental Control of the Melanocortin-4 Receptor by MRAP2 Proteins in Zebrafish
Accessory to Obesity? Melanocortin receptors are a family of cell membrane receptors that control diverse physiological functions… 
Highly Cited
2013
Highly Cited
2013
Chronic Treatment With a Melanocortin-4 Receptor Agonist Causes Weight Loss, Reduces Insulin Resistance, and Improves Cardiovascular Function in Diet-Induced Obese Rhesus Macaques
The melanocortin-4 receptor (MC4R) is well recognized as an important mediator of body weight homeostasis. Activation of MC4R… 
Highly Cited
2012
Highly Cited
2012
Melanocortin-4 receptor signaling is required for weight loss after gastric bypass surgery.
CONTEXT Roux-en-Y gastric bypass (RYGB) is one of the most effective long-term therapies for the treatment of severe obesity… 
Highly Cited
2004
Highly Cited
2004
Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system
Hypothalamic pro-opiomelanocortin (POMC) neurons help regulate long-term energy stores. POMC neurons are also found in the… 
Highly Cited
2004
Highly Cited
2004
Constitutive activity of the melanocortin-4 receptor is maintained by its N-terminal domain and plays a role in energy homeostasis in humans.
The melanocortin-4 receptor (MC4R), a centrally expressed G protein-coupled receptor (GPCR), is essential for the maintenance of… 
Review
2004
Review
2004
The central melanocortin system and the integration of short- and long-term regulators of energy homeostasis.
The importance of the central melanocortin system in the regulation of energy balance is highlighted by studies in transgenic… 
Highly Cited
2003
Highly Cited
2003
Transgenic Mice Expressing Green Fluorescent Protein under the Control of the Melanocortin-4 Receptor Promoter
The melanocortin-4 receptor (MC4-R) is an important regulator of energy homeostasis, and evidence suggests that MC4-R-expressing… 
Highly Cited
2002
Highly Cited
2002
A role for the melanocortin 4 receptor in sexual function
By using a combination of genetic, pharmacological, and anatomical approaches, we show that the melanocortin 4 receptor (MC4R… 
Highly Cited
1999
Highly Cited
1999
Phenotypes in three pedigrees with autosomal dominant obesity caused by haploinsufficiency mutations in the melanocortin-4 receptor gene.
Recently, haploinsufficiency mutations in the melanocortin-4 receptor gene (MC4-R) were detected which were assumed to lead to… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)