Melanocortin 4 Receptor

Known as: Receptor 4, Melanocortin, Receptor, Melanocortin 4, Receptor, MC4 
A melanocortin receptor subtype found primarily in BRAIN. It shows specificity for ALPHA-MSH; BETA-MSH and ADRENOCORTICOTROPIC HORMONE.
National Institutes of Health

Papers overview

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Highly Cited
2003
Highly Cited
2003
BACKGROUND Melanocortin 4 receptor (MC4R) deficiency is the commonest monogenic form of obesity. However, the clinical spectrum… (More)
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Highly Cited
2003
Highly Cited
2003
The melanocortin-4 receptor (MC4R) is critically involved in regulating energy balance, and obesity has been observed in mice… (More)
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Highly Cited
2003
Highly Cited
2003
The melanocortin 4 receptor (MC4-R) plays a pivotal role in maintaining energy homeostasis in rodents and humans. For example… (More)
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Highly Cited
2003
Highly Cited
2003
The melanocortin-4 receptor (MC4-R) is an important regulator of energy homeostasis, and evidence suggests that MC4-R-expressing… (More)
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Highly Cited
2001
Highly Cited
2001
In response to moderately increased dietary fat content, melanocortin-4 receptor-null mutant (MC4R−/−) mice exhibit hyperphagia… (More)
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Highly Cited
2000
Highly Cited
2000
By integrating an agonist satiety signal, provided by alpha-melanocyte-stimulating hormone (alpha-MSH), and an antagonist signal… (More)
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Highly Cited
2000
Highly Cited
2000
Over 20 severely obese subjects in 11 independent kindreds have been reported to have pathogenic heterozygous mutations in the… (More)
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Highly Cited
1999
Highly Cited
1999
Mutations reducing the functional activity of leptin, the leptin receptor, α–melanocyte stimulating hormone (α–MSH) and the… (More)
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Highly Cited
1997
Highly Cited
1997
The melanocortin-4 receptor (MC4-R) is a G protein-coupled, seven-transmembrane receptor expressed in the brain. Inactivation of… (More)
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Highly Cited
1994
Highly Cited
1994
POMC, the precursor of ACTH, MSH, and beta-endorphin peptides, is expressed in the pituitary and in two sites in the brain, in… (More)
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