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Meglutol

Known as: Meglutol [Chemical/Ingredient], 3 Hydroxy 3 methylglutaric Acid, Acid, 3-Hydroxy-3-methylpentanedioic 
An antilipemic agent which lowers cholesterol, triglycerides, serum beta-lipoproteins and phospholipids. It acts by interfering with the enzymatic… 
National Institutes of Health

Related topics

Related topics

16 relations

Narrower (4)

3-hydroxy-3-ethylglutaric acid3-methylglutaric acidgymnopilin 1gymnopilin 3

Broader (4)

Anticholesteremic AgentsEnzyme InhibitorsHydroxymethylglutaryl-CoA Reductase InhibitorsHypolipidemic Agents
In BloodMenotropinsagonistsanalogs & derivatives

Papers overview

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2009
2009
Leucine and mevalonate as precursors of serum cholesterol in man.
The incorporation of the radioactivities from simultaneously administered 3H-leucine and 14C-mevalonate to serum triglycerides as… 
1989
1989
Inhibitors of cholesterol biosynthesis: new route to phosphonic analogs of 3-hydroxy-3-methyl glutaric acid (meglutol)
Nous reportons ici la synthese d'analogues du meglutol comprenant un groupement phosphonate ou acide phosphonique a la place du… 
1985
1985
3-Alkyl-3-hydroxyglutaric acids: a new class of hypocholesterolemic HMG CoA reductase inhibitors. 1.
Derivatives of 3-hydroxy-3-methylglutaric acid (HMG), a portion of the substrate for HMG CoA reductase, were prepared and tested… 
1984
1984
The lipid-lowering effects of 3-hydroxy-3-methylglutaric acid and bile acid drainage in WHHL rabbits.
The effect of 3-hydroxy-3-methylglutaric acid (HMG) on serum cholesterol levels was investigated in Watanabe heritable… 
1983
1983
Synthesis of 3-hydroxy-3-cyclohexylbutyric acid derivatives. 1. Cyclic homologues of 3-hydroxy-3-methylglutaric acid.
Z and E isomers of 3-methyl-3-(carboxymethyl)hexahydro-1 (3H)-isobenzofuranones (I), lactones of 3-hydroxy-3-(2-carboxycyclohexyl… 
1982
1982
Gas-chromatographic/mass spectrometric detection of 3-hydroxy-3-methylglutaryl-CoA lyase deficiency in double first cousins.
Gas chromatography/mass spectrometry was used for the detection of 3-hydroxy-3-methylglutaryl-CoA lyase (EC 4.1.3.4) deficiency… 
1978
1978
Dissolution of gallstones in hamsters by 3-hydroxy-3-methylglutaric acid
Addition of 0.05–0.20% of 3-hydroxy-3-methylglutaric acid to a lithogenic hamster diet resulted in a marked reduction in the… 
1975
1975
Organ distribution of 3-hydroxy-3-methylglutaric acid, a potential anticholesterolemic agent.
The distribution of radioactivity after oral administration of 3-hydroxy-3-[3-14C]methylglutaric acid has been studied by whole… 
1975
1975
Preliminary toxicological investigations of 3-hydroxy-3-methylglutaric acid (HMG). I: Study of acute toxicity and of teratogenic activity in rats and mice.
The acute toxicity of 3-hydroxy-3-methylglutaric acid (HMG) was studied in mice. The LD50 was shown to be 7.33 g/kg p.o. and 3.23… 
1975
1975
Preliminary toxicological investigations of 3-hydroxy-3-methylglutaric acid (HMG). I: Study of acute toxicity and of teratogenic activity in rats and mice.
The acute toxicity of 3-hydroxy-3-methylglutaric acid (HMG) was studied in mice. The LD50 was shown to be 7.33 g/kg p.o. and 3.23…