Megakaryocyte Proliferation

Megakaryocyte Proliferation involves multiplication or reproduction through cell division of megakaryocytes, a large cell in the bone marrow with a… (More)
National Institutes of Health

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Bone MarrowMegakaryoblastsMegakaryocyte DifferentiationMegakaryocytes
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Papers overview

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2011
2011
In Vitro Megakaryocyte Differentiation and Proplatelet Formation in Ph-Negative Classical Myeloproliferative Neoplasms: Distinct Patterns in the Different Clinical Phenotypes
BACKGROUND Ph-negative myeloproliferative neoplasms (MPNs) are clonal disorders that include primary myelofibrosis (PMF… (More)
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2009
2009
Interference RNA (RNAi)-based silencing of endogenous thrombopoietin receptor (Mpl) in Dami cells resulted in decreased hNUDC-mediated megakaryocyte proliferation and differentiation.
Recently our laboratory reported evidence showing that hNUDC acts as an additional cytokine for thrombopoietin receptor (Mpl… (More)
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2004
2004
Megakaryocyte proliferation and ploidy regulated by the cytoplasmic tail of glycoprotein Ibalpha.
We have investigated the ability of glycoprotein (GP) Ibalpha, a megakaryocytic gene product, to sequester the signal… (More)
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2002
2002
Effects of anagrelide on in vivo megakaryocyte proliferation and maturation in essential thrombocythemia.
To define the mechanism by which anagrelide normalizes the platelet count in essential thrombocythemia, we studied in vivo… (More)
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2002
2002
Diagnostic and prognostic value of bone marrow angiogenesis and megakaryocyte c-Mpl expression in essential thrombocythemia.
The lack of diagnostic certainty in some patients makes it difficult to distinguish between primary and secondary forms of… (More)
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Highly Cited
1997
Highly Cited
1997
A lineage-selective knockout establishes the critical role of transcription factor GATA-1 in megakaryocyte growth and platelet development.
Transcription factor GATA-1 is essential for red blood cell maturation and, therefore, for survival of developing mouse embryos… (More)
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1997
1997
Tyrosine phosphorylation of the related adhesion focal tyrosine kinase in megakaryocytes upon stem cell factor and phorbol myristate acetate stimulation and its association with paxillin.
We have characterized signaling pathways involving the related adhesion focal tyrosine kinase (RAFTK, also known as PYK2 or CAK… (More)
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1996
1996
Thrombopoietin stimulates colony-forming unit-megakaryocyte proliferation and megakaryocyte maturation independently of cytokines that signal through the gp130 receptor subunit.
Thrombopoietin (Tpo), the ligand for the c-Mpl receptor, is a major regulator of megakaryopoiesis. Treatment of mice with Tpo… (More)
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1992
1992
The impact of megakaryocyte proliferation for the evolution of myelofibrosis
A histological study on sequential bone marrow biopsies in patients with chronic myeloid leukaemia (CML) was performed. We wished… (More)
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1984
1984
The relation of megakaryocyte ploidy to platelet volume.
To determine how alterations of megakaryocyte proliferation will affect platelet production, we measured mean platelet volume… (More)
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