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Megakaryocyte Proliferation

Megakaryocyte Proliferation involves multiplication or reproduction through cell division of megakaryocytes, a large cell in the bone marrow with a… Expand
National Institutes of Health

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Related topics

9 relations
Bone MarrowMegakaryoblastsMegakaryocyte DifferentiationMegakaryocytes
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Papers overview

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2014
2014
JAK2 and MPL protein levels determine TPO-induced megakaryocyte proliferation vs differentiation.
Megakaryopoiesis is a 2-step differentiation process, regulated by thrombopoietin (TPO), on binding to its cognate receptor… Expand
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2004
2004
Megakaryocyte proliferation and ploidy regulated by the cytoplasmic tail of glycoprotein Ibalpha.
We have investigated the ability of glycoprotein (GP) Ibalpha, a megakaryocytic gene product, to sequester the signal… Expand
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Highly Cited
2002
Highly Cited
2002
Effects of anagrelide on in vivo megakaryocyte proliferation and maturation in essential thrombocythemia.
To define the mechanism by which anagrelide normalizes the platelet count in essential thrombocythemia, we studied in vivo… Expand
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Highly Cited
2002
Highly Cited
2002
Diagnostic and prognostic value of bone marrow angiogenesis and megakaryocyte c-Mpl expression in essential thrombocythemia.
The lack of diagnostic certainty in some patients makes it difficult to distinguish between primary and secondary forms of… Expand
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Highly Cited
1997
Highly Cited
1997
A lineage‐selective knockout establishes the critical role of transcription factor GATA‐1 in megakaryocyte growth and platelet development
Transcription factor GATA‐1 is essential for red blood cell maturation and, therefore, for survival of developing mouse embryos… Expand
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Highly Cited
1997
Highly Cited
1997
Tyrosine Phosphorylation of the Related Adhesion Focal Tyrosine Kinase in Megakaryocytes upon Stem Cell Factor and Phorbol Myristate Acetate Stimulation and Its Association with Paxillin*
We have characterized signaling pathways involving the related adhesion focal tyrosine kinase (RAFTK, also known as PYK2 or CAK… Expand
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1996
1996
Thrombopoietin stimulates colony-forming unit-megakaryocyte proliferation and megakaryocyte maturation independently of cytokines that signal through the gp130 receptor subunit.
Thrombopoietin (Tpo), the ligand for the c-Mpl receptor, is a major regulator of megakaryopoiesis. Treatment of mice with Tpo… Expand
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Highly Cited
1988
Highly Cited
1988
Cytogenetic findings and clinical features in acute leukemia and transient myeloproliferative disorder in Down's syndrome
Cytogenetic, immunologic, and electron microscopic studies were performed on the blast cells of 28 pediatric patients with Down's… Expand
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Highly Cited
1984
Highly Cited
1984
The relation of megakaryocyte ploidy to platelet volume
  • J. Bessman
  • American journal of hematology
  • 1984
    • Corpus ID: 23604778
To determine how alterations of megakaryocyte proliferation will affect platelet production, we measured mean platelet volume… Expand
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Highly Cited
1970
Highly Cited
1970
Megakaryocytes in States of Altered Platelet Production: Cell Numbers, Size and DNA Content
Summary. Megakaryocytes have been studied in rats using objective methods, with assessment of numbers of cells, cell diameter and… Expand
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