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Matrix Metalloproteinase 17

Known as: Membrane Type 4 Matrix Metalloproteinase, Metalloproteinase 17, Matrix, Metalloproteinase, MMP17 
A membrane-type metalloproteinase that is associated with the CELL MEMBRANE via a GLYCOSYL-PHOSPHATIDYLINOSITOL linkage. It is synthesized as an… 
National Institutes of Health

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7 relations
In BloodMMP17 geneProcess of secretionaspects of radiation effects

Papers overview

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Highly Cited
2014
Highly Cited
2014
STIM1- and Orai1-mediated Ca2+ oscillation orchestrates invadopodium formation and melanoma invasion
Calcium signaling mediated by STIM1 and Orai1 activates Src to promote invadopodium assembly while simultaneously promoting MT1… 
Highly Cited
2009
Highly Cited
2009
Regulation of membrane-type 4 matrix metalloproteinase by SLUG contributes to hypoxia-mediated metastasis.
The hypoxic tumor environment has been shown to be critical to cancer metastasis through the promotion of angiogenesis, induction… 
Highly Cited
2004
Highly Cited
2004
ADAMTS4 (Aggrecanase-1) Activation on the Cell Surface Involves C-terminal Cleavage by Glycosylphosphatidyl Inositol-anchored Membrane Type 4-Matrix Metalloproteinase and Binding of the Activated…
C-terminal truncation of ADAMTS-4 from the p68 form to the p53 form is required for activation of its capacity to cleave the… 
Highly Cited
2004
Highly Cited
2004
The Low Density Lipoprotein Receptor-related Protein LRP Is Regulated by Membrane Type-1 Matrix Metalloproteinase (MT1-MMP) Proteolysis in Malignant Cells*
We demonstrate that the presentation of LRP and the subsequent uptake of its ligands by malignant cells are both strongly… 
Highly Cited
2003
Highly Cited
2003
Amoeboid shape change and contact guidance: T-lymphocyte crawling through fibrillar collagen is independent of matrix remodeling by MMPs and other proteases.
The passage of leukocytes through basement membranes involves proteolytic degradation of extracellular matrix (ECM) components… 
Highly Cited
2001
Highly Cited
2001
Matrix Metalloproteinase 9 Protects Mice from Anti–Glomerular Basement Membrane Nephritis through Its Fibrinolytic Activity
Matrix metalloproteinase (MMP)9/gelatinase B is increased in various nephropathies. To investigate its role, we used a genetic… 
Highly Cited
2000
Highly Cited
2000
Increased expression of matrix metalloproteinase 7 and 9 and membrane type 1‐matrix metalloproteinase in esophageal squamous cell carcinomas
The 5‐year survival rate of patients with submucosal (sm) esophageal carcinoma continues to be much worse than that with… 
Highly Cited
1998
Highly Cited
1998
Immunological characterization of cell‐surface and soluble forms of membrane type 1 matrix metalloproteinase in human breast cancer cells and in fibroblasts
Membrane type (MT) 1 matrix metalloproteinase (MMP) activates progelatinase A (pro–MMP‐2), a type IV collagenase, on the cell… 
Highly Cited
1997
Highly Cited
1997
Expression and tissue localization of membrane-types 1, 2, and 3 matrix metalloproteinases in human invasive breast carcinomas.
Activation of the zymogen of matrix metalloproteinase 2 (proMMP-2, progelatinase A) possibly is one of the key steps in invasion… 
Highly Cited
1996
Highly Cited
1996
Molecular cloning of a novel membrane-type matrix metalloproteinase from a human breast carcinoma.
A new member of the matrix metalloproteinase (MMP) family of enzymes has been cloned from a human breast carcinoma cDNA library… 
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