Malonate

Cannabinoid agonists might serve as neuroprotective agents in neurodegenerative disorders. Here, we examined this hypothesis in a… (More)

Glutathione peroxidase (GSHPx) is a critical intracellular enzyme involved in detoxification of hydrogen peroxide (H(2)O(2)) to… (More)

Dendrimers are highly branched macromolecules of low polydispersity that provide many exciting opportunities for design of novel… (More)

The gene defect in Huntington's disease (HD) may result in an impairment of energy metabolism. Malonate and 3-nitropropionic acid… (More)

Formation of H2O2 has been studied in rat heart mitochondria, pretreated with H2O2 and aminotriazole to lower their antioxidant… (More)

Although the Huntington's disease (HD) gene defect has been identified, the structure and function of the abnormal gene product… (More)

We previously showed that local striatal injections of malonate produce age-dependent excitotoxic lesions. In the present study… (More)

A potential mechanism of neuronal injury in neurodegenerative diseases is a defect in energy metabolism that may lead to slow… (More)

Intrastriatal injection of malonate, a reversible inhibitor of succinate dehydrogenase (SDH), produced age-dependent striatal… (More)

Manganese oxidation by manganese peroxidase (MnP) was investigated. Stoichiometric, kinetic, and MnII binding studies… (More)