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Macrophages, Alveolar

Known as: Macrophage, Pulmonary, Pulmonary Macrophage, Alveolar Macrophage 
Round, granular, mononuclear phagocytes found in the alveoli of the lungs. They ingest small inhaled particles resulting in degradation and… 
National Institutes of Health

Related topics

Related topics

8 relations
AlveolusImmune systemMicrobiologicalProcess of secretion

Broader (2)

Respiratory Systemmacrophage

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2010
Highly Cited
2010
Insight into human alveolar macrophage and M. tuberculosis interactions via metabolic reconstructions
Metabolic coupling of Mycobacterium tuberculosis to its host is foundational to its pathogenesis. Computational genome‐scale… 
Highly Cited
2009
Highly Cited
2009
Smoking-Dependent Reprogramming of Alveolar Macrophage Polarization: Implication for Pathogenesis of Chronic Obstructive Pulmonary Disease1
When exposed to a specific microenvironment, macrophages acquire either M1- or M2-polarized phenotypes associated with… 
Highly Cited
2003
Highly Cited
2003
Alveolar Macrophage–mediated Killing of Pneumocystis carinii f. sp. muris Involves Molecular Recognition by the Dectin-1 β-Glucan Receptor
Innate immune mechanisms against Pneumocystis carinii, a frequent cause of pneumonia in immunocompromised individuals, are not… 
Highly Cited
2002
Highly Cited
2002
Alveolar macrophage-mediated elastolysis: roles of matrix metalloproteinases, cysteine, and serine proteases.
Chronic obstructive pulmonary disease (COPD) is a common lung disease with cigarette smoking as the major etiological factor, but… 
Highly Cited
2001
Highly Cited
2001
Cigarette smoking reduces histone deacetylase 2 expression, enhances cytokine expression, and inhibits glucocorticoid actions in alveolar macrophages.
SPECIFIC AIMSGlucocorticoidsact, at least in part, through recruitment of histone deacetylases (HDACs) to sites of inflammatory… 
Highly Cited
1993
Highly Cited
1993
Downregulation of the antigen presenting cell function(s) of pulmonary dendritic cells in vivo by resident alveolar macrophages
Class II major histocompatibility complex (Ia)-bearing dendritic cells (DC) from airway epithelium and lung parenchyma express… 
Highly Cited
1989
Highly Cited
1989
Alveolar macrophage elimination in vivo is associated with an increase in pulmonary immune response in mice
A single intracheal dose of liposome-encapsuled dichloro-methylene- diphosphonate resulted in the elimination of alveolar… 
Highly Cited
1987
Highly Cited
1987
Normal alveolar epithelial lining fluid contains high levels of glutathione.
The epithelial cells on the alveolar surface of the human lower respiratory tract are vulnerable to toxic oxidants derived from… 
Highly Cited
1980
Highly Cited
1980
Receptor-mediated pinocytosis of mannose glycoconjugates by macrophages: Characterization and evidence for receptor recycling
Highly Cited
1978
Highly Cited
1978
Evidence for receptor-mediated binding of glycoproteins, glycoconjugates, and lysosomal glycosidases by alveolar macrophages.
Alveolar macrophages have been shown to bind glycoproteins and synthetic glycoconjugates (neoglycorpoteins) that have mannose, N… 
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