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Minimal information for studies of extracellular vesicles 2018 (MISEV2018): a position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines
TLDR
We revise and renew the “MISEV2014” guidelines for studies of extracellular vesicles based on evolution of the collective knowledge in the last four years. Expand
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A Salmonella virulence protein that inhibits cellular trafficking
Salmonella enterica requires a type III secretion system, designated Spi/Ssa, to survive and proliferate within macrophages. The Spi/Ssa system is encoded within the SPI‐2 pathogenicity island andExpand
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Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1.
RIN1 was originally identified by its ability to inhibit activated Ras and likely participates in multiple signaling pathways because it binds c-ABL and 14-3-3 proteins, in addition to Ras. RIN1 alsoExpand
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Sun2 Is a Novel Mammalian Inner Nuclear Membrane Protein*
Sun protein (Sun1 and Sun2) cDNAs were previously cloned based on the homology of their C-terminal regions (SUN (Sad1 and UNC) domain) with the Caenorhabditis elegans protein UNC-84 whose mutationExpand
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Modulation of Rab5 and Rab7 Recruitment to Phagosomes by Phosphatidylinositol 3-Kinase
ABSTRACT Phagosomal biogenesis is central for microbial killing and antigen presentation by leukocytes. However, the molecular mechanisms governing phagosome maturation are poorly understood. WeExpand
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The mannose receptor is a pattern recognition receptor involved in host defense.
The mannose receptor recognizes the patterns of carbohydrates that decorate the surfaces and cell walls of infectious agents. This macrophage and dendritic cell pattern-recognition receptor mediatesExpand
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Mannose receptor.
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A regulatory role for ARF6 in receptor-mediated endocytosis
Adenosine diphosphate-ribosylation factor 6 (ARF6), ARF6 mutants, and ARF1 were transiently expressed in Chinese hamster ovary cells, and the effects on receptor-mediated endocytosis were assessed.Expand
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A role for POR1, a Rac1‐interacting protein, in ARF6‐mediated cytoskeletal rearrangements
The ARF6 GTPase, the least conserved member of the ADP ribosylation factor (ARF) family, associates with the plasma membrane and intracellular endosome vesicles. Mutants of ARF6 defective in GTPExpand
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Phosphatidylinositol-4,5-bisphosphate hydrolysis directs actin remodeling during phagocytosis
The Rho GTPases play a critical role in initiating actin polymerization during phagocytosis. In contrast, the factors directing the disassembly of F-actin required for fission of the phagocyticExpand
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