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MX 68

Known as: MX-68 
National Institutes of Health

Papers overview

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2004
2004
Effect of MX‐68 on airway inflammation and hyperresponsiveness in mice and guinea‐pigs
MX‐68 is a newly synthesized antifolate, which is a derivative of methotrexate (MTX). In this paper, the effect of MX‐68 on… 
2002
2002
Polyglutamation of a novel antifolate, MX-68, is not necessary for its anti-arthritic effect.
2001
2001
Carrier-mediated hepatobiliary transport of a novel antifolate, N-[4-[(2,4-dianninopteridine-6-yl)methyl]-3,4-dihydro-2H-1,4-benzothiazin-7-yl]carbonyl-L-homoglutamic acid, in rats.
The hepatic uptake and biliary excretion of a novel methotrexate derivative, N-[4-[(2,4-diamminopteridine-6-yl)methyl]-3,4… 
2000
2000
Polyglutamation of antifolates is not required for induction of extracellular release of adenosine or expression of their anti-inflammatory effects.
1999
1999
Nonlinear disposition kinetics of a novel antifolate, MX-68, in rats.
The excretion and tissue distribution kinetics of a novel antifolate, MX-68, were evaluated under conditions of a continuous… 
1998
1998
A novel non-polyglutamable anti-folate, MX-68, inhibits the induction of experimental autoimmune uveitis in rats.
MX-68 is a novel antifolate which is chemically designed not to undergo intracellular polyglutamation thus preventing the… 
1997
1997
A novel antifolate, MX-68, inhibits the development of autoimmune disease in MRL/lpr mice.
We compared a novel unpolyglutamable antifolate, MX-68, with polyglutamable antifolate, methotrexate (MTX), for treatment of an… 
1997
1997
Immunosuppressive properties of MX-68, a novel unpolyglutamatable antifolate.
MX-68 is a novel unpolyglutamatable antifolate. We here reported the in vitro and in vivo immunosuppressive properties of MX-68… 
1997
1997
Preventive effect of a novel antifolate, MX-68, in murine systemic lupus erythematosus (SLE).
1996
1996
In vitro and in vivo biological activities of a novel nonpolyglutamable anti-folate, MX-68.
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