Mechanism of Anticancer Host Response Induced by OK-432, a Streptococcal Preparation, Mediated by Phagocytosis and Toll-Like Receptor 4 Signaling
It has previously been reported by our group that Toll-like receptor (TLR) 4 is involved in anticancer immunity induced by OK-432, a Streptococcus-derived immunotherapeutic agent. However the… Expand
Expression of Toll-Like Receptor 4 on Dendritic Cells Is Significant for Anticancer Effect of Dendritic Cell-Based Immunotherapy in Combination with an Active Component of OK-432, a Streptococcal…
A lipoteichoic acid-related molecule OK-PSA is an active component of OK-432, a Streptococcus-derived anticancer immunotherapeutic agent. In the present study, we first examined the effect of OK-PSA… Expand
Interleukin-6 (IL-6) induces the proliferation of synovial fibroblastic cells in the presence of soluble IL-6 receptor.
A number of investigators have reported that there are detectably elevated levels of interleukin-6 (IL-6) and soluble IL-6 receptor (sIL-6R) in the synovial fluids of rheumatoid arthritis (RA)… Expand
Involvement of Toll-like receptor 4 signaling in interferon-gamma production and antitumor effect by streptococcal agent OK-432.
- M. Okamoto, T. Oshikawa, +13 authors M. Sato
- Medicine, Biology
- Journal of the National Cancer Institute
- 19 February 2003
BACKGROUND The streptococcal agent OK-432 has been used for immunotherapy of head and neck cancer, among other malignancies, but its mechanism of action is unknown. Because the Toll-like receptor 4… Expand
Importance of formalin fixing conditions for HER2 testing in gastric cancer: immunohistochemical staining and fluorescence in situ hybridization
BackgroundAccurate and reliable assessment of human epidermal growth factor receptor type 2 (HER2) status is important for selecting patients with gastric cancer who may benefit from trastuzumab… Expand
Biological effect of OK-432 (picibanil) and possible application to dendritic cell therapy.
- Yoshiki Ryoma, Y. Moriya, M. Okamoto, Isao Kanaya, M. Saito, M. Sato
- Anticancer research
- 1 September 2004
OK-432 (Picibanil), a streptococcal preparation with potent biological response modifying activities, was approved in Japan as an anticancer agent in 1975. In the ensuing 30 years, since then, a… Expand
Schedule-dependent antitumor activity of the combination with erlotinib and docetaxel in human non-small cell lung cancer cells with EGFR mutation, KRAS mutation or both wild-type EGFR and KRAS.
- K. Furugaki, T. Iwai, M. Shirane, K. Kondoh, Y. Moriya, K. Mori
- Biology, Medicine
- Oncology reports
- 1 November 2010
Erlotinib is used as a standard treatment for recurrent advanced non-small cell lung cancer (NSCLC). Epidermal growth factor receptor (EGFR) mutations in NSCLC have been shown to be a predictive… Expand
Antitumor activity of trastuzumab in combination with chemotherapy in human gastric cancer xenograft models
- K. Fujimoto-Ouchi, F. Sekiguchi, H. Yasuno, Y. Moriya, K. Mori, Y. Tanaka
- Cancer Chemotherapy and Pharmacology
- 19 March 2007
PurposeTo clarify the antitumor activity of trastuzumab and its potential as an effective treatment for gastric cancer patients.MethodsLevels of HER2 expression in tumor tissues of gastric cancer… Expand
Tocilizumab, a humanized anti-interleukin-6 receptor antibody, ameliorates joint swelling in established monkey collagen-induced arthritis.
- Y. Uchiyama, K. Yorozu, M. Hashizume, Y. Moriya, M. Mihara
- Biological & pharmaceutical bulletin
- 1 June 2008
We examined if tocilizumab, humanized anti-interleukin-6 receptor (IL-6R) antibody, can ameliorate joint swelling after the onset of arthritis in collagen-induced arthritis (CIA). CIA was induced by… Expand
Impact of bevacizumab in combination with erlotinib on EGFR‐mutated non–small cell lung cancer xenograft models with T790M mutation or MET amplification
- K. Furugaki, Junko Fukumura, +9 authors N. Harada
- International journal of cancer
- 15 February 2016
Erlotinib (ERL), an epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor, shows notable efficacy against non–small cell lung cancer (NSCLC) harboring EGFR mutations. Bevacizumab (BEV), a… Expand