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MTHFD2 gene

Known as: methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase, Methylenetetrahydrofolate Dehydrogenase (NADP+ Dependent) 2, Methenyltetrahydrofolate Cyclohydrolase Gene, METHYLENETETRAHYDROFOLATE DEHYDROGENASE 2 
This gene is involved in the metabolism of folic acid.
National Institutes of Health

Related topics

Related topics

5 relations
HydrolysisMTHFD1 geneOxidation-Reductionfolic acid metabolism

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
The effect of MTHFD2 on the proliferation and migration of colorectal cancer cell lines
Purpose Methylenetetrahydrofolate dehydrogenase 2 (MTHFD2) is a tetramethylfolate dehydrogenase enzyme involved in folate… 
2019
2019
Effect of circ MTHFD2 on resistance to pemetrexed in gastric cancer through regulating expression of miR-124.
OBJECTIVE The aim of this study was to explore the effect of circ MTHFD2 on resistance to pemetrexed (MTA) in gastric cancer by… 
2019
2019
Upregulation of miR-504-3p is associated with favorable prognosis of acute myeloid leukemia and may serve as a tumor suppressor by targeting MTHFD2.
OBJECTIVE Deregulated expression of miRNAs contributes to the development of acute myeloid leukemia (AML). miR-504-3p, one of… 
Highly Cited
2018
Highly Cited
2018
Cancer stem-like properties and gefitinib resistance are dependent on purine synthetic metabolism mediated by the mitochondrial enzyme MTHFD2
Tumor recurrence is attributable to cancer stem-like cells (CSCs), the metabolic mechanisms of which currently remain obscure… 
2018
2018
Protein interaction and functional data indicate MTHFD2 involvement in RNA processing and translation
The folate-coupled metabolic enzyme MTHFD2 is overexpressed in many tumor types and required for cancer cell proliferation, and… 
2018
2018
SOX7 Target Genes and Their Contribution to Its Tumor Suppressive Function
SOX7 is a transcription factor and acts as a tumor suppressor, but its target genes in cancers are poorly explored. We revealed… 
2017
2017
miR-92a Inhibits Proliferation and Induces Apoptosis by Regulating Methylenetetrahydrofolate Dehydrogenase 2 (MTHFD2) Expression in Acute Myeloid Leukemia
Aberrant expression of microRNA-92a (miR-92a) has been investigated in various cancers. However, the function and mechanism of… 
2017
2017
Gene expression meta-analysis in diffuse low-grade glioma and the corresponding histological subtypes
Diffuse low-grade glioma (DLGG) is a well-differentiated, slow-growing tumour with an inherent tendency to progress to high-grade… 
Highly Cited
2015
Highly Cited
2015
The folate-coupled enzyme MTHFD2 is a nuclear protein and promotes cell proliferation
Folate metabolism is central to cell proliferation and a target of commonly used cancer chemotherapeutics. In particular, the… 
2014
2014
KRAS Mutation Status Is Associated with Enhanced Dependency on Folate Metabolism Pathways in Non–Small Cell Lung Cancer Cells
KRAS gene mutation is linked to poor prognosis and resistance to therapeutics in non–small cell lung cancer (NSCLC). In this… 
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