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MSH6 protein, human

Known as: 160-kDa GTBP, human, MutS-alpha 160 kDa subunit, human, G/T Mismatch Binding Protein 
DNA mismatch repair protein Msh6 (1360 aa, ~153 kDa) is encoded by the human MSH6 gene. This protein is involved in the DNA damage response.
National Institutes of Health

Related topics

Related topics

13 relations
Cell NucleusDNA RepairDNA Repair GeneDNA repair protein

Papers overview

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Highly Cited
2005
Highly Cited
2005
Human MutScv recognizes damaged DNA base pairs containing 06-methylguanine, 04-methylthymine, or the cisplatin-d(GpG) adduct
Bacterial and mammalian mismatch repair systems have been implicated in the cellular response to certain types of DNA damage, and… 
Highly Cited
2003
Highly Cited
2003
Microsatellite instability is a predictive factor of the tumor response to irinotecan in patients with advanced colorectal cancer.
The aim of our study was to assess the relationship between colorectal tumor responsiveness to irinotecan and microsatellite… 
Review
2003
Review
2003
The Hereditary Nonpolyposis Colorectal Cancer Syndrome: Genetics and Clinical Implications
In the United States, an individual's lifetime risk for developing some form of cancer is estimated to be as high as 40% (1… 
Highly Cited
2001
Highly Cited
2001
hMSH3 and hMSH6 interact with PCNA and colocalize with it to replication foci.
Proliferating cell nuclear antigen (PCNA) has been implicated in eukaryotic postreplicative mismatch correction, but the nature… 
Highly Cited
2001
Highly Cited
2001
Inverse relationship between microsatellite instability and K-ras and p53 gene alterations in colon cancer.
Highly Cited
1999
Highly Cited
1999
MSH2 and MSH6 are required for removal of adenine misincorporated opposite 8-oxo-guanine in S. cerevisiae.
Highly Cited
1998
Highly Cited
1998
Isolation of MutSβ from Human Cells and Comparison of the Mismatch Repair Specificities of MutSβ and MutSα*
A human MSH2-human MSH3 (hMSH2·hMSH3) complex of approximately 1:1 stoichiometry (human MutSβ (hMutSβ)) has been demonstrated in… 
Highly Cited
1996
Highly Cited
1996
Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair.
Saccharomyces cerevisiae encodes six genes, MSH1-6, which encode proteins related to the bacterial MutS protein. In this study… 
Highly Cited
1996
Highly Cited
1996
hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6.
The genetic and biochemical properties of three human MutS homologues, hMSH2, hMSH3, and hMSH6, have been examined. The full… 
Highly Cited
1995
Highly Cited
1995
GTBP, a 160-kilodalton protein essential for mismatch-binding activity in human cells.
DNA mismatch recognition and binding in human cells has been thought to be mediated by the hMSH2 protein. Here it is shown that… 
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