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MSH6 gene

Known as: mutS homolog 6, G/T MISMATCH-BINDING PROTEIN, MutS, E. COLI, HOMOLOG OF, 6 
This gene is involved in mismatch repair and plays a role in several cancers.
National Institutes of Health

Related topics

Related topics

9 relations
Colorectal cancer, hereditary nonpolyposis, type 1DNA RepairHereditary Non-Polyposis Colon Cancer Type 2Hereditary Nonpolyposis Colorectal Cancer

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MSH6 wt Allele

Papers overview

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Highly Cited
2011
Highly Cited
2011
DNA mismatch repair gene polymorphisms affect survival in pancreatic cancer.
PURPOSE DNA mismatch repair (MMR) maintains genomic stability and mediates cellular response to DNA damage. We aim to demonstrate… 
Review
2010
Review
2010
Immunohistochemistry for PMS2 and MSH6 alone can replace a four antibody panel for mismatch repair deficiency screening in colorectal adenocarcinoma
Aims: Currently, testing for mismatch repair deficiency in colorectal cancers is initiated by performing immunohistochemistry… 
Highly Cited
2005
Highly Cited
2005
A Homozygous Mutation in MSH6 Causes Turcot Syndrome
Heterozygous mutations in one of the DNA mismatch repair genes cause hereditary nonpolyposis colorectal cancer (MIM114500… 
Highly Cited
2004
Highly Cited
2004
Lower incidence of colorectal cancer and later age of disease onset in 27 families with pathogenic MSH6 germline mutations compared with families with MLH1 or MSH2 mutations: the German Hereditary…
PURPOSE The aim of the study was the analysis of the involvement and phenotypic manifestations of MSH6 germline mutations in… 
Highly Cited
2002
Highly Cited
2002
Somatic expansion behaviour of the (CTG)n repeat in myotonic dystrophy knock-in mice is differentially affected by Msh3 and Msh6 mismatch-repair proteins.
The mechanism of expansion of the (CTG)n repeat in myotonic dystrophy (DM1) patients and the cause of its pathobiological effects… 
Highly Cited
2002
Highly Cited
2002
Molecular and clinical characteristics of MSH6 variants: an analysis of 25 index carriers of a germline variant.
The MSH6 gene is one of the mismatch-repair genes involved in hereditary nonpolyposis colorectal cancer (HNPCC). Three hundred… 
Highly Cited
2001
Highly Cited
2001
Atypical HNPCC owing to MSH6 germline mutations: analysis of a large Dutch pedigree
Hereditary non-polyposis colorectal cancer (HNPCC) is the most common genetic susceptibility syndrome for colorectal cancer… 
Highly Cited
2000
Highly Cited
2000
The DNA mismatch repair genes Msh3 and Msh6 cooperate in intestinal tumor suppression.
Repair of mismatches in DNA in mammalian cells is mediated by a complex of proteins that are members of two highly conserved… 
Highly Cited
1999
Highly Cited
1999
HNPCC-like cancer predisposition in mice through simultaneous loss of Msh3 and Msh6 mismatch-repair protein functions
Cancer predisposition in hereditary non-polyposis colon cancer (HNPCC) is caused by defects in DNA mismatch repair (MMR… 
Highly Cited
1998
Highly Cited
1998
Functional overlap in mismatch repair by human MSH3 and MSH6.
Three human genes, hMSH2, hMSH3, and hMSH6, are homologues of the bacterial MutS gene whose products bind DNA mismatches to… 
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