Skip to search formSkip to main contentSkip to account menu

MSH6 gene

Known as: mutS homolog 6, G/T MISMATCH-BINDING PROTEIN, MutS, E. COLI, HOMOLOG OF, 6 
This gene is involved in mismatch repair and plays a role in several cancers.
National Institutes of Health

Related topics

Related topics

9 relations
Colorectal cancer, hereditary nonpolyposis, type 1DNA RepairHereditary Non-Polyposis Colon Cancer Type 2Hereditary Nonpolyposis Colorectal Cancer

Narrower (1)

MSH6 wt Allele

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2018
2018
Nucleosomes around a mismatched base pair are excluded via an Msh2-dependent reaction with the aid of SNF2 family ATPase Smarcad1
Here, Terui et al. studied the mechanisms underlying chromatin remodeling that occurs during MMR. They show that the eukaryotic… 
2007
2007
An individual with Muir-Torre syndrome found to have a pathogenic MSH6 gene mutation
Mutations reported to cause Muir-Torre syndrome (MTS) have previously been reported in the mismatch repair genes MLH1 and MSH2… 
2007
2007
Meiotic Recombination in Drosophila Msh6 Mutants Yields Discontinuous Gene Conversion Tracts
Crossovers (COs) generated through meiotic recombination are important for the correct segregation of homologous chromosomes… 
2007
2007
MSH2 118T>C and MSH6 159C>T promoter polymorphisms and the risk of colorectal cancer.
The most important indicator of colorectal cancer (CRC) risk is the presence of family history of the disease. Inherited genetic… 
2006
2006
MSH6 germline mutations in early-onset colorectal cancer patients without family history of the disease
Germline MLH1 and MSH2 mutations are scarce in young colorectal cancer patients with negative family history of the disease. To… 
2004
2004
Six novel heterozygous MLH1, MSH2, and MSH6 and one homozygous MLH1 germline mutations in hereditary nonpolyposis colorectal cancer.
2004
2004
Mutation analysis of the MLH1, MSH2 and MSH6 genes in patients with double primary cancers of the colorectum and the endometrium: A population‐based study in northern Sweden
Hereditary nonpolyposis colorectal cancer (HNPCC) is an autosomal dominant disorder that predisposes to predominantly colorectal… 
Highly Cited
2003
Highly Cited
2003
MSH6 germline mutations are rare in colorectal cancer families
Germline mutations in MSH6 can cause HNPCC, which is associated with a tumor phenotype featuring MSI. However, tumors arising in… 
2002
2002
Identification and functional characterization of the promoter region of the human MSH6 gene
Postreplicative mismatch repair (MMR) corrects polymerase errors arising during DNA replication. Consistent with this role, the… 
2001
2001
Requirement for Msh6, but not for Swi4 (Msh3), in Msh2-dependent repair of base-base mismatches and mononucleotide loops in Schizosaccharomyces pombe.
The msh6 mismatch repair gene of Schizosaccharomyces pombe was cloned, sequenced, and inactivated. Strains bearing all… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)