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MSH2 gene

Known as: HNPCC, mutS homolog 2, MSH2 
This gene plays a role in DNA mismatch repair mutations in the gene result in hereditary nonpolyposis colorectal cancer-1.
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
Epimutations in the germline, such as methylation of the MLH1 gene, may contribute to hereditary cancer syndrome in human, but… 
Highly Cited
2003
Highly Cited
2003
The identification of germline mutations in families with HNPCC is hampered by genetic heterogeneity and clinical variability. In… 
Highly Cited
2001
Highly Cited
2001
We investigated a possible role of the mismatch-repair gene MLH3 in hereditary nonpolyposis colorectal cancer by scanning for… 
Review
2001
Review
2001
  • R. Fishel
  • Cancer Research
  • 2001
  • Corpus ID: 3566616
The “mutator hypothesis” asserts that gene alterations that increase the rate of spontaneous mutation (mutators) underlie… 
Highly Cited
1999
Highly Cited
1999
Nature Genet. 21, 25–32 (1999). Table 3; High–density microarrays Details of Affymetrix software are as follows. GeneChip® EDMT… 
Highly Cited
1999
Highly Cited
1999
Hereditary non-polyposis colorectal cancer (HNPCC) is a common autosomal dominant condition characterized by early onset… 
Review
1997
Highly Cited
1996
Highly Cited
1996
Saccharomyces cerevisiae encodes six genes, MSH1-6, which encode proteins related to the bacterial MutS protein. In this study… 
Highly Cited
1996
Highly Cited
1996
Highly Cited
1994
Highly Cited
1994
The international collaborative group on HNPCC (ICG-HNPCC) was established in 1989. The original aims of the group were: (1) to…