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MSH2 gene

Known as: HNPCC, mutS homolog 2, MSH2 
This gene plays a role in DNA mismatch repair mutations in the gene result in hereditary nonpolyposis colorectal cancer-1.
National Institutes of Health

Related topics

Related topics

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Colorectal cancer, hereditary nonpolyposis, type 1DNA Mismatch Repair Protein MSH2, humanDNA RepairHereditary Nonpolyposis Colorectal Neoplasms
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MSH2 wt Allele

Papers overview

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Highly Cited
2006
Highly Cited
2006
Heritable germline epimutation of MSH2 in a family with hereditary nonpolyposis colorectal cancer
Epimutations in the germline, such as methylation of the MLH1 gene, may contribute to hereditary cancer syndrome in human, but… 
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Review
2005
Review
2005
Hereditary ovarian cancer.
Family history is the strongest risk factor for ovarian cancer. Three clinical manifestations of hereditary ovarian cancer have… 
Highly Cited
2003
Highly Cited
2003
Molecular analysis of hereditary nonpolyposis colorectal cancer in the United States: high mutation detection rate among clinically selected families and characterization of an American founder…
The identification of germline mutations in families with HNPCC is hampered by genetic heterogeneity and clinical variability. In… 
Highly Cited
2003
Highly Cited
2003
Genetic counseling and testing in families with hereditary nonpolyposis colorectal cancer.
BACKGROUND Genetic testing to refine cancer risk is available. However, little is known about factors affecting the uptake of… 
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Highly Cited
2001
Highly Cited
2001
A role for MLH3 in hereditary nonpolyposis colorectal cancer
We investigated a possible role of the mismatch-repair gene MLH3 in hereditary nonpolyposis colorectal cancer by scanning for… 
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Review
2001
Review
2001
The selection for mismatch repair defects in hereditary nonpolyposis colorectal cancer: revising the mutator hypothesis.
  • R. Fishel
  • Cancer research
  • 2001
  • Corpus ID: 3566616
The “mutator hypothesis” asserts that gene alterations that increase the rate of spontaneous mutation (mutators) underlie… 
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Highly Cited
1999
Highly Cited
1999
Familial endometrial cancer in female carriers of MSH6 germline mutations
Hereditary non-polyposis colorectal cancer (HNPCC) is a common autosomal dominant condition characterized by early onset… 
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Highly Cited
1996
Highly Cited
1996
Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair.
Saccharomyces cerevisiae encodes six genes, MSH1-6, which encode proteins related to the bacterial MutS protein. In this study… 
Highly Cited
1996
Highly Cited
1996
Meiotic Pachytene Arrest in MLH1-Deficient Mice
Germ line mutations in DNA mismatch repair genes including MLH1 cause hereditary nonpolyposis colon cancer. To understand the… 
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Highly Cited
1994
Highly Cited
1994
The International Collaborative Group on HNPCC.
The international collaborative group on HNPCC (ICG-HNPCC) was established in 1989. The original aims of the group were: (1) to… 
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