MSH2 gene

Known as: HNPCC, mutS homolog 2, MSH2 
This gene plays a role in DNA mismatch repair mutations in the gene result in hereditary nonpolyposis colorectal cancer-1.
National Institutes of Health

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Colorectal cancer, hereditary nonpolyposis, type 1DNA Mismatch Repair Protein MSH2, humanDNA RepairHereditary Nonpolyposis Colorectal Neoplasms
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MSH2 wt Allele

Papers overview

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Highly Cited
2010
Highly Cited
2010
Somatic hypermethylation of MSH2 is a frequent event in Lynch Syndrome colorectal cancers.
Heritable germline epimutations in MSH2 have been reported in a few Lynch syndrome families that lacked germline mutations in the… (More)
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Highly Cited
2006
Highly Cited
2006
Heritable germline epimutation of MSH2 in a family with hereditary nonpolyposis colorectal cancer
Epimutations in the germline, such as methylation of the MLH1 gene, may contribute to hereditary cancer syndrome in human, but… (More)
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Highly Cited
2005
Highly Cited
2005
Spectrum and frequencies of mutations in MSH2 and MLH1 identified in 1,721 German families suspected of hereditary nonpolyposis colorectal cancer.
Mutations in DNA MMR genes, mainly MSH2 and MLH1, account for the majority of HNPCC, an autosomal dominant predisposition to… (More)
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Review
2004
Review
2004
Mutations Associated with HNPCC Predisposition — Update of ICG-HNPCC/INSiGHT Mutation Database
In 1994, the International Collaborative Group on Hereditary Nonpolyposis Colorectal Cancer (ICG-HNPCC) established an… (More)
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Highly Cited
2003
Highly Cited
2003
Distinguishing right from left colon by the pattern of gene expression.
Distinct epidemiological and clinicopathological characteristics of colorectal carcinomas (CRCs) based on their anatomical… (More)
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Highly Cited
2002
Highly Cited
2002
Genomic deletions of MSH2 and MLH1 in colorectal cancer families detected by a novel mutation detection approach
Hereditary non-polyposis colorectal cancer is an autosomal dominant condition due to germline mutations in DNA-mismatch-repair… (More)
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Highly Cited
2002
Highly Cited
2002
Evaluation of microsatellite instability and immunohistochemistry for the prediction of germ-line MSH2 and MLH1 mutations in hereditary nonpolyposis colon cancer families.
Forty-eight hereditary nonpolyposis colorectal carcinoma (HNPCC) families for which a tumor sample was available were evaluated… (More)
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Highly Cited
1999
Highly Cited
1999
Familial endometrial cancer in female carriers of MSH6 germline mutations
cancer (HNPCC) is a common autosomal dominant condition characterized by early onset colorectal cancer as well as other tumour… (More)
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Highly Cited
1996
Highly Cited
1996
Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair.
Saccharomyces cerevisiae encodes six genes, MSH1-6, which encode proteins related to the bacterial MutS protein. In this study… (More)
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Highly Cited
1996
Highly Cited
1996
Meiotic Pachytene Arrest in MLH1-Deficient Mice
Germ line mutations in DNA mismatch repair genes including MLH1 cause hereditary nonpolyposis colon cancer. To understand the… (More)
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