MSH2 gene

Known as: HNPCC, mutS homolog 2, MSH2 
This gene plays a role in DNA mismatch repair mutations in the gene result in hereditary nonpolyposis colorectal cancer-1.
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
Heritable germline epimutations in MSH2 have been reported in a few Lynch syndrome families that lacked germline mutations in the… (More)
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Highly Cited
2006
Highly Cited
2006
Epimutations in the germline, such as methylation of the MLH1 gene, may contribute to hereditary cancer syndrome in human, but… (More)
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Highly Cited
2005
Highly Cited
2005
Mutations in DNA MMR genes, mainly MSH2 and MLH1, account for the majority of HNPCC, an autosomal dominant predisposition to… (More)
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Review
2004
Review
2004
In 1994, the International Collaborative Group on Hereditary Nonpolyposis Colorectal Cancer (ICG-HNPCC) established an… (More)
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Highly Cited
2003
Highly Cited
2003
Distinct epidemiological and clinicopathological characteristics of colorectal carcinomas (CRCs) based on their anatomical… (More)
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Highly Cited
2002
Highly Cited
2002
Hereditary non-polyposis colorectal cancer is an autosomal dominant condition due to germline mutations in DNA-mismatch-repair… (More)
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Highly Cited
2002
Highly Cited
2002
Forty-eight hereditary nonpolyposis colorectal carcinoma (HNPCC) families for which a tumor sample was available were evaluated… (More)
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Highly Cited
1999
Highly Cited
1999
cancer (HNPCC) is a common autosomal dominant condition characterized by early onset colorectal cancer as well as other tumour… (More)
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Highly Cited
1996
Highly Cited
1996
Saccharomyces cerevisiae encodes six genes, MSH1-6, which encode proteins related to the bacterial MutS protein. In this study… (More)
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Highly Cited
1996
Highly Cited
1996
Germ line mutations in DNA mismatch repair genes including MLH1 cause hereditary nonpolyposis colon cancer. To understand the… (More)
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