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MSH2 gene

Known as: HNPCC, mutS homolog 2, MSH2 
This gene plays a role in DNA mismatch repair mutations in the gene result in hereditary nonpolyposis colorectal cancer-1.
National Institutes of Health

Related topics

Related topics

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Colorectal cancer, hereditary nonpolyposis, type 1DNA Mismatch Repair Protein MSH2, humanDNA RepairHereditary Nonpolyposis Colorectal Neoplasms

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MSH2 wt Allele

Papers overview

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Highly Cited
2007
Highly Cited
2007
The common sense model of self‐regulation and psychological adjustment to predictive genetic testing: a prospective study
This prospective study explored the contribution of illness representations and coping to cancer‐related distress in unaffected… 
Highly Cited
2006
Highly Cited
2006
Pathogenicity of MSH2 missense mutations is typically associated with impaired repair capability of the mutated protein.
BACKGROUND & AIMS Inherited deleterious mutations in mismatch repair genes MLH1, MSH2, and MSH6 predispose to hereditary… 
2005
2005
Germline mutations in the MYH gene in Swedish familial and sporadic colorectal cancer.
Biallelic germline mutations in the base excision repair gene MYH have been shown to predispose to a proportion of multiple… 
Review
2004
Review
2004
Genetic factors and colorectal cancer in Ashkenazi Jews
The observed increased incidence of colorectal cancer in Ashkenazi Jews compared to other populations is unexplained but likely… 
2004
2004
Chemotherapy resistant ovarian cancer in carriers of an hMSH2 mutation?
Hereditary Non-Polyposis Colorectal Cancer (HNPCC, Lynch syndrome) is an autosomal dominant condition of cancer susceptibility… 
1999
1999
Missense and nonsense mutations in codon 659 of MLH1 cause aberrant splicing of messenger RNA in HNPCC kindreds
Germline mutations that give rise to premature termination codons in mRNAs have frequently been associated with aberrant… 
Review
1996
Review
1996
Familial risk and colorectal cancer.
Highly Cited
1995
Highly Cited
1995
Detection of new mutations in six out of 10 Swiss HNPCC families by genomic sequencing of the hMSH2 and hMLH1 genes.
The cancer predisposition in most HNPCC families is believed to be associated with mutations in the human mismatch repair gene… 
Highly Cited
1994
Highly Cited
1994
Accumulation of multiple mutations in tumour suppressor genes during colorectal tumorigenesis in HNPCC patients.
1991
1991
Evidence supporting exclusion of the DCC gene and a portion of chromosome 18q as the locus for susceptibility to hereditary nonpolyposis colorectal carcinoma in five kindreds.
Hereditary non-polyposis colorectal carcinoma (HNPCC) syndrome is characterized by early onset and multiple cancers of… 
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