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MSH2 gene
Known as:
HNPCC
, mutS homolog 2
, MSH2
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This gene plays a role in DNA mismatch repair mutations in the gene result in hereditary nonpolyposis colorectal cancer-1.
National Institutes of Health
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Related topics
Related topics
10 relations
Colorectal cancer, hereditary nonpolyposis, type 1
DNA Mismatch Repair Protein MSH2, human
DNA Repair
Hereditary Nonpolyposis Colorectal Neoplasms
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MSH2 wt Allele
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2006
Highly Cited
2006
Heritable germline epimutation of MSH2 in a family with hereditary nonpolyposis colorectal cancer
T. Chan
,
S. Yuen
,
+8 authors
S. Leung
Nature Genetics
2006
Corpus ID: 20200831
Epimutations in the germline, such as methylation of the MLH1 gene, may contribute to hereditary cancer syndrome in human, but…
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Highly Cited
2003
Highly Cited
2003
Molecular analysis of hereditary nonpolyposis colorectal cancer in the United States: high mutation detection rate among clinically selected families and characterization of an American founder…
A. Wagner
,
Alicia Barrows
,
+19 authors
R. Fodde
American Journal of Human Genetics
2003
Corpus ID: 22514729
The identification of germline mutations in families with HNPCC is hampered by genetic heterogeneity and clinical variability. In…
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Highly Cited
2001
Highly Cited
2001
A role for MLH3 in hereditary nonpolyposis colorectal cancer
Ying Wu
,
M. J. Berends
,
+10 authors
R. Hofstra
Nature Genetics
2001
Corpus ID: 32512676
We investigated a possible role of the mismatch-repair gene MLH3 in hereditary nonpolyposis colorectal cancer by scanning for…
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Review
2001
Review
2001
The selection for mismatch repair defects in hereditary nonpolyposis colorectal cancer: revising the mutator hypothesis.
R. Fishel
Cancer Research
2001
Corpus ID: 3566616
The “mutator hypothesis” asserts that gene alterations that increase the rate of spontaneous mutation (mutators) underlie…
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Highly Cited
1999
Highly Cited
1999
Options available—from start to finish—for obtaining expression data by microarray
D. Bowtell
Nature Genetics
1999
Corpus ID: 13137898
Nature Genet. 21, 25–32 (1999). Table 3; High–density microarrays Details of Affymetrix software are as follows. GeneChip® EDMT…
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Highly Cited
1999
Highly Cited
1999
Familial endometrial cancer in female carriers of MSH6 germline mutations
J. Wijnen
,
Wiljo de Leeuw
,
+16 authors
R. Fodde
Nature Genetics
1999
Corpus ID: 30251596
Hereditary non-polyposis colorectal cancer (HNPCC) is a common autosomal dominant condition characterized by early onset…
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Review
1997
Review
1997
Mutations predisposing to hereditary nonpolyposis colorectal cancer.
P. Peltomäki
,
A. de la Chapelle
Advances in Cancer Research
1997
Corpus ID: 23484308
Highly Cited
1996
Highly Cited
1996
Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair.
G. Marsischky
,
N. Filosi
,
M. Kane
,
R. Kolodner
Genes & Development
1996
Corpus ID: 36155203
Saccharomyces cerevisiae encodes six genes, MSH1-6, which encode proteins related to the bacterial MutS protein. In this study…
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Highly Cited
1996
Highly Cited
1996
Meiotic Pachytene Arrest in MLH1-Deficient Mice
W. Edelmann
,
P. Cohen
,
+10 authors
R. Kucherlapati
Cell
1996
Corpus ID: 16562725
Highly Cited
1994
Highly Cited
1994
The International Collaborative Group on HNPCC.
H. Vasen
,
J. Mecklin
,
P. Khan
,
H. Lynch
Anticancer Research
1994
Corpus ID: 33910190
The international collaborative group on HNPCC (ICG-HNPCC) was established in 1989. The original aims of the group were: (1) to…
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