DNA Mismatch Repair Protein MSH2, human

Known as: MutS Protein Homolog 2, MSH2, hMSH2 
DNA mismatch repair protein Msh2 (934 aa, ~105 kDa) is encoded by the human MSH2 gene. This protein is involved in DNA mismatch repair.
National Institutes of Health

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Highly Cited
2003
Highly Cited
2003
Frequent BRAF mutations were reported recently in a variety of human malignancies, including colorectal cancer. In this study, we… (More)
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Highly Cited
2002
Highly Cited
2002
In the human DNA mismatch repair (MMR) system, hMSH2 forms the hMutSalpha and hMutSbeta complexes with hMSH6 and hMSH3… (More)
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Highly Cited
2000
Highly Cited
2000
Steady-state levels of human DNA mismatch repair (MMR) transcripts and proteins were measured in MMR-proficient and -deficient… (More)
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Highly Cited
1999
Highly Cited
1999
Cancer predisposition in hereditary non-polyposis colon cancer (HNPCC) is caused by defects in DNA mismatch repair (MMR… (More)
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Highly Cited
1997
Highly Cited
1997
In vitro studies have shown that loss of DNA mismatch repair due to lack of either hMSH2 or hMLH1 activity results in low-level… (More)
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Highly Cited
1996
Highly Cited
1996
Selection of cells for resistance to cisplatin, a well-recognized mutagen, could result in mutations in genes involved in DNA… (More)
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Highly Cited
1996
Highly Cited
1996
A two-hybrid system was used to screen yeast and human expression libraries for proteins that interact with mismatch repair… (More)
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Highly Cited
1996
Highly Cited
1996
BACKGROUND The antitumor drug cis-diamminedichloroplatinum(II) (cis-DDP or cisplatin) exerts its cytotoxic effects through the… (More)
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Highly Cited
1995
Highly Cited
1995
A mismatch-binding heterodimer of hMSH2 and a 160-kilodalton polypeptide has been isolated from HeLa cells by virtue of its… (More)
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Highly Cited
1993
Highly Cited
1993
We have identified a human homolog of the bacterial MutS and S. cerevisiae MSH proteins, called hMSH2. Expression of hMSH2 in E… (More)
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