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DNA Mismatch Repair Protein MSH2, human

Known as: MutS Protein Homolog 2, MSH2, hMSH2 
DNA mismatch repair protein Msh2 (934 aa, ~105 kDa) is encoded by the human MSH2 gene. This protein is involved in DNA mismatch repair.
National Institutes of Health

Related topics

Related topics

14 relations
Adenosine TriphosphatasesCell NucleusDNA RepairDNA Repair Gene

Papers overview

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Highly Cited
2007
Highly Cited
2007
Activin type 2 receptor restoration in MSI-H colon cancer suppresses growth and enhances migration with activin.
BACKGROUND & AIMS Colon cancers with high-frequency microsatellite instability (MSI-H) develop frameshift mutations in tumor… 
Highly Cited
2006
Highly Cited
2006
Demonstration and Characterization of Mutations Induced by Helicobacter pylori Organisms in Gastric Epithelial Cells
Background:  Helicobacter pylori gastritis increases gastric cancer risk. Microsatellite instability‐type mutations are secondary… 
2002
2002
Loss of heterozygosity, microsatellite instability, and mismatch repair protein alterations in the radial growth phase of cutaneous malignant melanomas
Little is known about genomic alterations during development of the radial growth phase (RGP) of cutaneous malignant melanomas… 
Highly Cited
2001
Highly Cited
2001
Loss of DNA mismatch repair imparts defective cdc2 signaling and G(2) arrest responses without altering survival after ionizing radiation.
Our previous data demonstrated that cells deficient in MutL homologue-1 (MLH1) expression had a reduced and shorter G(2) arrest… 
Highly Cited
2001
Highly Cited
2001
Adenosine nucleotide modulates the physical interaction between hMSH2 and BRCA1
We have identified the physical interaction between the Breast Cancer susceptibility gene product BRCA1 and the Hereditary Non… 
Review
2000
Review
2000
Characterization of MLH1 and MSH2 DNA mismatch repair proteins in cell lines of the NCI anticancer drug screen
Purpose and methods: The lack of a functional DNA mismatch repair (MMR) pathway has been recognized as a common characteristic of… 
Highly Cited
2000
Highly Cited
2000
hMLH1 and hMSH2 expression correlates with allelic imbalance on chromosome 3p in non-small cell lung carcinomas.
DNA mismatch repair genes have been implicated in the pathogenesis and predisposition of certain malignancies through a mutator… 
Highly Cited
2000
Highly Cited
2000
Genetic instability is associated with histological transformation of follicle center lymphoma
Follicle center lymphoma (FCL) is an indolent B cell non-Hodgkin's lymphoma (NHL) characterized genetically by the t(14;18… 
Highly Cited
1996
Highly Cited
1996
Human MutSα Specifically Binds to DNA Containing Aminofluorene and Acetylaminofluorene Adducts*
Defects in mismatch repair are associated with several types of cancer. It is also generally believed that environmental… 
1996
1996
A truncated hMSH2 transcript occurs as a common variant in the population: implications for genetic diagnosis.
Germline mutations of the hMSH2 gene are responsible for many cases of hereditary nonpolyposis colorectal cancer. While screening… 
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