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MS 27-275

Known as: MS 275, MS-275, HDAC inhibitor SNDX-275 
A synthetic benzamide derivative. MS-275 binds to and inhibits histone deacetylase, an enzyme that regulates chromatin structure and gene… 
National Institutes of Health

Related topics

Related topics

2 relations
azacitidine/MS-275

Broader (1)

entinostat

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Histone deacetylase inhibition reduces pulmonary vein arrhythmogenesis through calcium regulation.
Review
2013
Review
2013
Proteasome inhibitors in acute leukemia
Proteasome inhibition has been recognized as a novel treatment modality in hematologic malignancies. Initially, the reversible… 
Highly Cited
2007
Highly Cited
2007
Histone deacetylase inhibitor MS-275 alone or combined with bortezomib or sorafenib exhibits strong antiproliferative action in human cholangiocarcinoma cells.
AIM To investigate the antiproliferative effect of the histone deacetylase (HDAC) inhibitor MS-275 on cholangiocarcinoma cells… 
Highly Cited
2007
Highly Cited
2007
Antitumor activity of the histone deacetylase inhibitor MS‐275 in prostate cancer models
Histone deacetylase (HDAC) inhibitors represent a novel class of therapeutic agents with antitumor activity currently in clinical… 
2007
2007
The histone deacetylase inhibitors depsipeptide and MS-275, enhance TRAIL gene therapy of LNCaP prostate cancer cells without adverse effects in normal prostate epithelial cells
Gene therapy of cancer using adenovirus as a single treatment modality has met limited success and efforts to enhance therapeutic… 
Review
2006
Review
2006
Histone deacetylase inhibitors as novel anti-inflammatory agents.
Histone acetylation regulates inflammatory gene expression and also plays a role in diverse functions such as DNA repair and cell… 
Highly Cited
2004
Highly Cited
2004
Class I Histone Deacetylase-Selective Novel Synthetic Inhibitors Potently Inhibit Human Tumor Proliferation
We have developed previously a class of synthetic hybrid histone deacetylase (HDAC) inhibitors, which were built from hydroxamic… 
2004
2004
Expression and functional characterization of recombinant human HDAC1 and HDAC3.
Highly Cited
2003
Highly Cited
2003
Inhibition of PI-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor-mediated apoptosis through p44/42 MAP kinase inactivation and abrogation of p21CIP1/WAF1 induction rather…
Effects of the PI-3 kinase inhibitor LY294002 (LY) have been examined in relation to responses of human leukemia cells to histone… 
Highly Cited
2002
Highly Cited
2002
Transcriptional Regulation of the Transforming Growth Factor β Type II Receptor Gene by Histone Acetyltransferase and Deacetylase Is Mediated by NF-Y in Human Breast Cancer Cells*
Transcriptional repression of the transforming growth factor-β (TGF-β) type II receptor (TβRII) gene is one of several mechanisms… 
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