MS 27-275

Known as: MS 275, MS-275, HDAC inhibitor SNDX-275 
A synthetic benzamide derivative. MS-275 binds to and inhibits histone deacetylase, an enzyme that regulates chromatin structure and gene… (More)
National Institutes of Health

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Highly Cited
2009
Highly Cited
2009
Lysine acetylation is a reversible posttranslational modification of proteins and plays a key role in regulating gene expression… (More)
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Highly Cited
2006
Highly Cited
2006
The association of the histone deacetylase (HDAC) inhibitor valproate (VPA) with atypical antipsychotics has become a frequent… (More)
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Highly Cited
2006
Highly Cited
2006
MS-275 is a benzamide derivative with potent histone deacetylase (HDAC) inhibitory and antitumor activity in preclinical models… (More)
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Highly Cited
2006
Highly Cited
2006
Histone acetyltransferases (HATs), and p300/CBP in particular, have been implicated in cancer cell growth and survival, and as… (More)
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Highly Cited
2005
Highly Cited
2005
PURPOSE The objective of this study was to define the maximum-tolerated dose (MTD), the recommended phase II dose, the dose… (More)
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Review
2005
Review
2005
Histones are small basic proteins that, by complexing wtih DNA, form the nucleosome core. Repetitive units of this nucleosome led… (More)
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Highly Cited
2004
Highly Cited
2004
Histone deacetylase (HDAC) inhibitors are undergoing clinical evaluation for cancer therapy. Because HDAC modulates chromatin… (More)
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Highly Cited
2003
Highly Cited
2003
Effects of the histone deacetylase (HDAC) inhibitor MS-275 have been examined in human leukemia and lymphoma cells (U937, HL-60… (More)
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Highly Cited
2002
Highly Cited
2002
The antitumor efficacy of the synthetic benzamide derivative MS-27-275 (MS-275), an inhibitor of histone deacetylation [T. Suzuki… (More)
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Highly Cited
1999
Highly Cited
1999
Synthetic benzamide derivatives were investigated for their ability to inhibit histone deacetylase (HDA). In this study, one of… (More)
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