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MS 27-275

Known as: MS 275, MS-275, HDAC inhibitor SNDX-275 
A synthetic benzamide derivative. MS-275 binds to and inhibits histone deacetylase, an enzyme that regulates chromatin structure and gene… 
National Institutes of Health

Related topics

Related topics

2 relations
azacitidine/MS-275

Broader (1)

entinostat

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2013
Review
2013
Proteasome inhibitors in acute leukemia
Proteasome inhibition has been recognized as a novel treatment modality in hematologic malignancies. Initially, the reversible… 
2012
2012
Antitumor activity of Chidamide in hepatocellular carcinoma cell lines.
Chidamide, the structural analog of MS-275, is a novel and promising histone deacetylase (HDAC) inhibitor for use in cancer… 
Highly Cited
2008
Highly Cited
2008
Defining the molecular action of HDAC inhibitors and synergism with androgen deprivation in ERG‐positive prostate cancer
Gene fusions between prostate‐specific, androgen responsive TMPRSS2 gene and oncogenic ETS factors, such as ERG, occur in up to… 
Highly Cited
2007
Highly Cited
2007
Histone deacetylase inhibitor MS-275 alone or combined with bortezomib or sorafenib exhibits strong antiproliferative action in human cholangiocarcinoma cells.
AIM To investigate the antiproliferative effect of the histone deacetylase (HDAC) inhibitor MS-275 on cholangiocarcinoma cells… 
Highly Cited
2007
Highly Cited
2007
Antitumor activity of the histone deacetylase inhibitor MS‐275 in prostate cancer models
Histone deacetylase (HDAC) inhibitors represent a novel class of therapeutic agents with antitumor activity currently in clinical… 
2006
2006
SK-7041, a new histone deacetylase inhibitor, induces G2-M cell cycle arrest and apoptosis in pancreatic cancer cell lines.
Highly Cited
2005
Highly Cited
2005
Epigenetic Modulation of Retinoic Acid Receptor β2 by the Histone Deacetylase Inhibitor MS-275 in Human Renal Cell Carcinoma
Purpose: Histone deacetylase (HDAC) inhibitors have been shown to reverse epigenetic repression of certain genes, including… 
Highly Cited
2004
Highly Cited
2004
Class I Histone Deacetylase-Selective Novel Synthetic Inhibitors Potently Inhibit Human Tumor Proliferation
We have developed previously a class of synthetic hybrid histone deacetylase (HDAC) inhibitors, which were built from hydroxamic… 
Highly Cited
2003
Highly Cited
2003
Inhibition of PI-3 kinase sensitizes human leukemic cells to histone deacetylase inhibitor-mediated apoptosis through p44/42 MAP kinase inactivation and abrogation of p21CIP1/WAF1 induction rather…
Effects of the PI-3 kinase inhibitor LY294002 (LY) have been examined in relation to responses of human leukemia cells to histone… 
Highly Cited
2002
Highly Cited
2002
Transcriptional Regulation of the Transforming Growth Factor β Type II Receptor Gene by Histone Acetyltransferase and Deacetylase Is Mediated by NF-Y in Human Breast Cancer Cells*
Transcriptional repression of the transforming growth factor-β (TGF-β) type II receptor (TβRII) gene is one of several mechanisms… 
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