entinostat

Known as: Carbamic Acid, N-[[4-[[(2-aminophenyl)amino]carbonyl]phenyl]methyl]-, 3- pyridinylmethyl Ester, Carbamic acid, N-((4-(((2-aminophenyl)amino)carbonyl)phenyl)methyl)-, 3- pyridinylmethyl ester 
A synthetic benzamide derivative with potential antineoplastic activity. Entinostat binds to and inhibits histone deacetylase, an enzyme that… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2000-2017
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Papers overview

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2015
2015
Mortality following breast cancer diagnosis is mainly due to the development of distant metastasis. To escape from the primary… (More)
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Highly Cited
2014
Highly Cited
2014
PURPOSE Although azacitidine (AZA) improves survival in patients with high-risk myelodysplastic syndrome, the overall response… (More)
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2014
2014
The DNA methyltransferase (DNMT) inhibitor vidaza (5-Azacytidine) in combination with the histone deacetylase inhibitor… (More)
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Highly Cited
2013
Highly Cited
2013
PURPOSE Entinostat is an oral isoform selective histone deacetylase inhibitor that targets resistance to hormonal therapies in… (More)
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Highly Cited
2012
Highly Cited
2012
PURPOSE Histone deacetylase inhibitors (HDACis) have been shown to overcome resistance to epidermal growth factor receptor… (More)
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2012
2012
BACKGROUND Immunosuppressive factors such as regulatory T cells (Tregs) limit the efficacy of immunotherapies. Histone… (More)
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2011
Highly Cited
2011
UNLABELLED Epigenetic alterations are strongly associated with the development of cancer. We conducted a phase I/II trial of… (More)
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2011
2011
Approximately 25% of breast cancers do not express the estrogen receptor-α (ERα) and consequently do not respond to endocrine… (More)
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Highly Cited
2009
Highly Cited
2009
Sequential administration of DNA methyltransferase (DNMT) inhibitors and histone deacetylase (HDAC) inhibitors has demonstrated… (More)
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Highly Cited
2009
Highly Cited
2009
Increasing evidence shows aberrant hypermethylation of genes occurring in and potentially contributing to pathogenesis of myeloid… (More)
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